The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions

Prion diseases are fatal infectious neurodegenerative disorders that affect both humans and animals. The autocatalytic conversion of the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pathogenesis. AR-12 is an IND-approved derivative of celecoxib that d...

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Detalles Bibliográficos
Autores principales: Abdulrahman, Basant A., Abdelaziz, Dalia, Thapa, Simrika, Lu, Li, Jain, Shubha, Gilch, Sabine, Proniuk, Stefan, Zukiwski, Alexander, Schatzl, Hermann M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730578/
https://www.ncbi.nlm.nih.gov/pubmed/29242534
http://dx.doi.org/10.1038/s41598-017-17770-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730578/
https://www.ncbi.nlm.nih.gov/pubmed/29242534
http://dx.doi.org/10.1038/s41598-017-17770-8

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