Ezh2 phosphorylation state determines its capacity to maintain CD8(+) T memory precursors for antitumor immunity

Memory T cells sustain effector T-cell production while self-renewing in reaction to persistent antigen; yet, excessive expansion reduces memory potential and impairs antitumor immunity. Epigenetic mechanisms are thought to be important for balancing effector and memory differentiation; however, the...

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Detalles Bibliográficos
Autores principales: He, Shan, Liu, Yongnian, Meng, Lijun, Sun, Hongxing, Wang, Ying, Ji, Yun, Purushe, Janaki, Chen, Pan, Li, Changhong, Madzo, Jozef, Issa, Jean-Pierre, Soboloff, Jonathan, Reshef, Ran, Moore, Bethany, Gattinoni, Luca, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730609/
https://www.ncbi.nlm.nih.gov/pubmed/29242551
http://dx.doi.org/10.1038/s41467-017-02187-8

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