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Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives

The kynurenine aminotransferase (KAT) enzymes are pyridoxal 5′-phosphate-dependent homodimers that catalyse the irreversible transamination of kynurenine into kynurenic acid (KYNA) in the tryptophan metabolic pathway. Kynurenic acid is implicated in cognitive diseases such as schizophrenia, and seve...

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Detalles Bibliográficos
Autores principales:	Jayawickrama, Gayan S., Nematollahi, Alireza, Sun, Guanchen, Gorrell, Mark D., Church, W. Bret
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730616/ https://www.ncbi.nlm.nih.gov/pubmed/29242525 http://dx.doi.org/10.1038/s41598-017-17979-7

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