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DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Phosphoinositide lipids (PPIs) are enriched in the nucleus and are accumulated at DNA damage sites. Here, we investigate roles of nuclear PPIs in DNA damage response by sequestering specific PPIs with the expression of nuclear-targeted PH domains, which inhibits recruitment of Ataxia telangiectasia...

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Detalles Bibliográficos
Autores principales:	Wang, Yu-Hsiu, Hariharan, Anushya, Bastianello, Giulia, Toyama, Yusuke, Shivashankar, G. V., Foiani, Marco, Sheetz, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730617/ https://www.ncbi.nlm.nih.gov/pubmed/29242514 http://dx.doi.org/10.1038/s41467-017-01805-9

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