Effect of phosphodiesterase inhibitors in the bladder

Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cystei...

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Detalles Bibliográficos
Autores principales: Chughtai, Bilal, Ali, Aizaz, Dunphy, Claire, Kaplan, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Second Military Medical University 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730687/
https://www.ncbi.nlm.nih.gov/pubmed/29264117
http://dx.doi.org/10.1016/j.ajur.2015.04.014
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author Chughtai, Bilal
Ali, Aizaz
Dunphy, Claire
Kaplan, Steven A.
author_facet Chughtai, Bilal
Ali, Aizaz
Dunphy, Claire
Kaplan, Steven A.
author_sort Chughtai, Bilal
collection PubMed
description Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H(2)S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate.
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spelling pubmed-57306872017-12-20 Effect of phosphodiesterase inhibitors in the bladder Chughtai, Bilal Ali, Aizaz Dunphy, Claire Kaplan, Steven A. Asian J Urol Article Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients. PDE5 inhibitors mediate their effects through several pathways including cAMP, NO/cGMP, K-channel modulated pathways, and the l-cysteine/H(2)S pathway. PDE5 inhibitors exert their effect in muscle cells, nerve fibers, and interstitial cells (ICs). The use of PDE5 inhibitors led to improvement in LUTS. This included urodynamic parameters. PDE5 inhibitors may play a significant role in LUTS due to their effect on the bladder rather than the prostate. Second Military Medical University 2015-01 2015-04-16 /pmc/articles/PMC5730687/ /pubmed/29264117 http://dx.doi.org/10.1016/j.ajur.2015.04.014 Text en © 2015 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier (Singapore) Pte Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chughtai, Bilal
Ali, Aizaz
Dunphy, Claire
Kaplan, Steven A.
Effect of phosphodiesterase inhibitors in the bladder
title Effect of phosphodiesterase inhibitors in the bladder
title_full Effect of phosphodiesterase inhibitors in the bladder
title_fullStr Effect of phosphodiesterase inhibitors in the bladder
title_full_unstemmed Effect of phosphodiesterase inhibitors in the bladder
title_short Effect of phosphodiesterase inhibitors in the bladder
title_sort effect of phosphodiesterase inhibitors in the bladder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730687/
https://www.ncbi.nlm.nih.gov/pubmed/29264117
http://dx.doi.org/10.1016/j.ajur.2015.04.014
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