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NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA

Hepatitis C viruses (HCV) encode a helicase enzyme that is essential for viral replication and assembly (nonstructural protein 3 [NS3]). This helicase has become the focus of extensive basic research on the general helicase mechanism, and it is also of interest as a novel drug target. Despite the im...

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Detalles Bibliográficos
Autores principales:	Zhou, Ting, Ren, Xiaoming, Adams, Rebecca L., Pyle, Anna Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Structure and Assembly
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730761/ https://www.ncbi.nlm.nih.gov/pubmed/29070684 http://dx.doi.org/10.1128/JVI.01253-17

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