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Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study

Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We...

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Autores principales: Jary, Hannah R., Aston, Stephen, Ho, Antonia, Giorgi, Emanuele, Kalata, Newton, Nyirenda, Mulinda, Mallewa, Jane, Peterson, Ingrid, Gordon, Stephen B., Mortimer, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730861/
https://www.ncbi.nlm.nih.gov/pubmed/29387802
http://dx.doi.org/10.12688/wellcomeopenres.12621.1
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author Jary, Hannah R.
Aston, Stephen
Ho, Antonia
Giorgi, Emanuele
Kalata, Newton
Nyirenda, Mulinda
Mallewa, Jane
Peterson, Ingrid
Gordon, Stephen B.
Mortimer, Kevin
author_facet Jary, Hannah R.
Aston, Stephen
Ho, Antonia
Giorgi, Emanuele
Kalata, Newton
Nyirenda, Mulinda
Mallewa, Jane
Peterson, Ingrid
Gordon, Stephen B.
Mortimer, Kevin
author_sort Jary, Hannah R.
collection PubMed
description Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We conducted a case-control study in urban Malawi to examine the association between exposure to household air pollution and pneumonia in adults. Methods: Hospitalized patients with radiologically confirmed pneumonia (cases) and healthy community controls underwent 48 hours of ambulatory and household particulate matter (µg/m (3)) and carbon monoxide (ppm) exposure monitoring. Multivariate logistic regression, stratified by HIV status, explored associations between these and other potential risk factors with pneumonia. Results: 145 (117 HIV-positive; 28 HIV-negative) cases and 253 (169 HIV-positive; 84 HIV-negative) controls completed follow up. We found no evidence of association between household air pollution exposure and pneumonia in HIV-positive (e.g. ambulatory particulate matter adjusted odds ratio [aOR] 1.00 [95% CI 1.00–1.01, p=0.141]) or HIV-negative (e.g. ambulatory particulate matter aOR 1.00 [95% CI 0.99–1.01, p=0.872]) participants. Chronic respiratory disease was associated with pneumonia in both HIV-positive (aOR 28.07 [95% CI 9.29–84.83, p<0.001]) and HIV-negative (aOR 104.27 [95% CI 12.86–852.35, p<0.001]) participants. Conclusions: We found no evidence that exposure to household air pollution is associated with pneumonia in Malawian adults. In contrast, chronic respiratory disease was strongly associated with pneumonia.
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spelling pubmed-57308612017-12-18 Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study Jary, Hannah R. Aston, Stephen Ho, Antonia Giorgi, Emanuele Kalata, Newton Nyirenda, Mulinda Mallewa, Jane Peterson, Ingrid Gordon, Stephen B. Mortimer, Kevin Wellcome Open Res Research Article Background: Four million people die each year from diseases caused by exposure to household air pollution. There is an association between exposure to household air pollution and pneumonia in children (half a million attributable deaths a year); however, whether this is true in adults is unknown. We conducted a case-control study in urban Malawi to examine the association between exposure to household air pollution and pneumonia in adults. Methods: Hospitalized patients with radiologically confirmed pneumonia (cases) and healthy community controls underwent 48 hours of ambulatory and household particulate matter (µg/m (3)) and carbon monoxide (ppm) exposure monitoring. Multivariate logistic regression, stratified by HIV status, explored associations between these and other potential risk factors with pneumonia. Results: 145 (117 HIV-positive; 28 HIV-negative) cases and 253 (169 HIV-positive; 84 HIV-negative) controls completed follow up. We found no evidence of association between household air pollution exposure and pneumonia in HIV-positive (e.g. ambulatory particulate matter adjusted odds ratio [aOR] 1.00 [95% CI 1.00–1.01, p=0.141]) or HIV-negative (e.g. ambulatory particulate matter aOR 1.00 [95% CI 0.99–1.01, p=0.872]) participants. Chronic respiratory disease was associated with pneumonia in both HIV-positive (aOR 28.07 [95% CI 9.29–84.83, p<0.001]) and HIV-negative (aOR 104.27 [95% CI 12.86–852.35, p<0.001]) participants. Conclusions: We found no evidence that exposure to household air pollution is associated with pneumonia in Malawian adults. In contrast, chronic respiratory disease was strongly associated with pneumonia. F1000 Research Limited 2017-10-24 /pmc/articles/PMC5730861/ /pubmed/29387802 http://dx.doi.org/10.12688/wellcomeopenres.12621.1 Text en Copyright: © 2017 Jary HR et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jary, Hannah R.
Aston, Stephen
Ho, Antonia
Giorgi, Emanuele
Kalata, Newton
Nyirenda, Mulinda
Mallewa, Jane
Peterson, Ingrid
Gordon, Stephen B.
Mortimer, Kevin
Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title_full Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title_fullStr Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title_full_unstemmed Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title_short Household air pollution, chronic respiratory disease and pneumonia in Malawian adults: A case-control study
title_sort household air pollution, chronic respiratory disease and pneumonia in malawian adults: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730861/
https://www.ncbi.nlm.nih.gov/pubmed/29387802
http://dx.doi.org/10.12688/wellcomeopenres.12621.1
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