Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo

OBJECTIVES: Suramin is an old drug used for the treatment of African sleeping sickness. We investigated therapeutic repositioning of suramin to protect against cartilage damage, as suramin may interact with tissue inhibitor of metalloproteinase-3 (TIMP3). METHODS: In vitro extracellular matrix (ECM)...

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Detalles Bibliográficos
Autores principales: Guns, Laura-An, Monteagudo, Silvia, Kvasnytsia, Maryna, Kerckhofs, Greet, Vandooren, Jennifer, Opdenakker, Ghislain, Lories, Rik J, Cailotto, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Animal Models
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730881/
https://www.ncbi.nlm.nih.gov/pubmed/29299344
http://dx.doi.org/10.1136/rmdopen-2017-000604

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