The genetic framework for development of nephrolithiasis

Over 1%–15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been la...

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Detalles Bibliográficos
Autores principales: Vasudevan, Vinaya, Samson, Patrick, Smith, Arthur D., Okeke, Zeph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Second Military Medical University 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730897/
https://www.ncbi.nlm.nih.gov/pubmed/29264202
http://dx.doi.org/10.1016/j.ajur.2016.11.003
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author Vasudevan, Vinaya
Samson, Patrick
Smith, Arthur D.
Okeke, Zeph
author_facet Vasudevan, Vinaya
Samson, Patrick
Smith, Arthur D.
Okeke, Zeph
author_sort Vasudevan, Vinaya
collection PubMed
description Over 1%–15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge; however, several candidate genes have been implicated in the development of nephrolithiasis. In this review, we will review current data on the genetic inheritance of stone disease, as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis.
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spelling pubmed-57308972017-12-20 The genetic framework for development of nephrolithiasis Vasudevan, Vinaya Samson, Patrick Smith, Arthur D. Okeke, Zeph Asian J Urol Review Over 1%–15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge; however, several candidate genes have been implicated in the development of nephrolithiasis. In this review, we will review current data on the genetic inheritance of stone disease, as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis. Second Military Medical University 2017-01 2016-11-28 /pmc/articles/PMC5730897/ /pubmed/29264202 http://dx.doi.org/10.1016/j.ajur.2016.11.003 Text en © 2017 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Vasudevan, Vinaya
Samson, Patrick
Smith, Arthur D.
Okeke, Zeph
The genetic framework for development of nephrolithiasis
title The genetic framework for development of nephrolithiasis
title_full The genetic framework for development of nephrolithiasis
title_fullStr The genetic framework for development of nephrolithiasis
title_full_unstemmed The genetic framework for development of nephrolithiasis
title_short The genetic framework for development of nephrolithiasis
title_sort genetic framework for development of nephrolithiasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730897/
https://www.ncbi.nlm.nih.gov/pubmed/29264202
http://dx.doi.org/10.1016/j.ajur.2016.11.003
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