Oral Field Cancerization and Its Clinical Implications in the Management in Potentially Malignant Disorders

Oral cancer is one of the common malignancies reported in India. Most of these cancers are preceded by potentially malignant disorders. Despite improvements in the management strategies of these cancers the posttreatment prognosis has remained poor. The 5-year survival rates of oral cancers in most...

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Detalles Bibliográficos
Autores principales: Sathiasekar, Anisha Cynthia, Mathew, Deepu George, Jaish Lal, M. S., Arul Prakash, A. A., Goma Kumar, K. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731019/
https://www.ncbi.nlm.nih.gov/pubmed/29284929
http://dx.doi.org/10.4103/jpbs.JPBS_109_17
Descripción
Sumario:Oral cancer is one of the common malignancies reported in India. Most of these cancers are preceded by potentially malignant disorders. Despite improvements in the management strategies of these cancers the posttreatment prognosis has remained poor. The 5-year survival rates of oral cancers in most countries are still below 50%. The poor outcomes in oral cancer prevention and treatment can be due to nature of the spread of genetically altered cells as fields within the epithelial compartment. The conventional management protocols need to be modified taking into consideration the field spread of genetically altered cells.

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