Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

BACKGROUND: Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle. METHODS: To gain insight into pathogenesis of aberrant muscle regeneration in LGMD2A, we used a paradigm of cardiot...

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Detalles Bibliográficos
Autores principales: Yalvac, Mehmet E., Amornvit, Jakkrit, Braganza, Cilwyn, Chen, Lei, Hussain, Syed-Rehan A., Shontz, Kimberly M., Montgomery, Chrystal L., Flanigan, Kevin M., Lewis, Sarah, Sahenk, Zarife
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731057/
https://www.ncbi.nlm.nih.gov/pubmed/29241457
http://dx.doi.org/10.1186/s13395-017-0146-6

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