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The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy

BACKGROUND: The lipoprotein subfraction particle profile can be used to improve clinical assessments of cardiovascular disease risk and contribute to early detection of atherogenic dyslipidemia. Lipid alterations in gestational diabetes have been extensively studied, but the results have been incons...

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Autores principales: Chen, Yanmin, Du, Mengkai, Xu, Jianyun, Chen, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731065/
https://www.ncbi.nlm.nih.gov/pubmed/29241449
http://dx.doi.org/10.1186/s12944-017-0627-y
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author Chen, Yanmin
Du, Mengkai
Xu, Jianyun
Chen, Danqing
author_facet Chen, Yanmin
Du, Mengkai
Xu, Jianyun
Chen, Danqing
author_sort Chen, Yanmin
collection PubMed
description BACKGROUND: The lipoprotein subfraction particle profile can be used to improve clinical assessments of cardiovascular disease risk and contribute to early detection of atherogenic dyslipidemia. Lipid alterations in gestational diabetes have been extensively studied, but the results have been inconsistent. Here, we investigated serum lipoprotein subfraction particle levels and their association with glucose metabolic status in pregnancy. METHODS: Twenty-eight pregnant women with gestational diabetes and 56 pregnant women with normal glucose tolerance matched for body mass index were enrolled in this study. We assessed fasting serum lipid concentrations and lipoprotein subfraction particle levels in participants between 24 and 28 weeks of gestation. RESULTS: The level of low-density lipoprotein (LDL) cholesterol was significantly lower in women with gestational diabetes than in those with normal glucose tolerance, but the triglyceride and high-density lipoprotein (HDL) cholesterol levels of the two groups were similar. Lipoprotein particle analysis showed that very-low-density lipoprotein (VLDL) particle number and the small dense LDL particle/large buoyant LDL particle (sdLDL-P/lbLDL-P) ratio were significantly higher in women with gestational diabetes than in those with normal glucose tolerance (P = 0.013 and P = 0.015, respectively). In multivariate analysis, fasting glucose was independently and positively associated with sdLDL-P/lbLDL-P ratio even after adjustment for maternal age, gestational weight gain, BMI and LDL cholesterol (standardized Beta = 0.214, P = 0.029). CONCLUSIONS: The sdLDL-P/lbLDL-P ratio is higher in GDM compared with non-diabetic pregnant women, and positively and independently associated with fasting glucose in pregnant women.
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spelling pubmed-57310652017-12-19 The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy Chen, Yanmin Du, Mengkai Xu, Jianyun Chen, Danqing Lipids Health Dis Research BACKGROUND: The lipoprotein subfraction particle profile can be used to improve clinical assessments of cardiovascular disease risk and contribute to early detection of atherogenic dyslipidemia. Lipid alterations in gestational diabetes have been extensively studied, but the results have been inconsistent. Here, we investigated serum lipoprotein subfraction particle levels and their association with glucose metabolic status in pregnancy. METHODS: Twenty-eight pregnant women with gestational diabetes and 56 pregnant women with normal glucose tolerance matched for body mass index were enrolled in this study. We assessed fasting serum lipid concentrations and lipoprotein subfraction particle levels in participants between 24 and 28 weeks of gestation. RESULTS: The level of low-density lipoprotein (LDL) cholesterol was significantly lower in women with gestational diabetes than in those with normal glucose tolerance, but the triglyceride and high-density lipoprotein (HDL) cholesterol levels of the two groups were similar. Lipoprotein particle analysis showed that very-low-density lipoprotein (VLDL) particle number and the small dense LDL particle/large buoyant LDL particle (sdLDL-P/lbLDL-P) ratio were significantly higher in women with gestational diabetes than in those with normal glucose tolerance (P = 0.013 and P = 0.015, respectively). In multivariate analysis, fasting glucose was independently and positively associated with sdLDL-P/lbLDL-P ratio even after adjustment for maternal age, gestational weight gain, BMI and LDL cholesterol (standardized Beta = 0.214, P = 0.029). CONCLUSIONS: The sdLDL-P/lbLDL-P ratio is higher in GDM compared with non-diabetic pregnant women, and positively and independently associated with fasting glucose in pregnant women. BioMed Central 2017-12-14 /pmc/articles/PMC5731065/ /pubmed/29241449 http://dx.doi.org/10.1186/s12944-017-0627-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Yanmin
Du, Mengkai
Xu, Jianyun
Chen, Danqing
The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title_full The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title_fullStr The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title_full_unstemmed The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title_short The small dense LDL particle/large buoyant LDL particle ratio is associated with glucose metabolic status in pregnancy
title_sort small dense ldl particle/large buoyant ldl particle ratio is associated with glucose metabolic status in pregnancy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731065/
https://www.ncbi.nlm.nih.gov/pubmed/29241449
http://dx.doi.org/10.1186/s12944-017-0627-y
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