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Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a very aggressive and lethal tumor, which arises from the epithelial cells of bile ducts. CCA comprises about 3% of all gastrointestinal malignancies and its incidence is on the rise in the recent years. Anatomically, it is classified into intrahepatic, perihilar, or extr...

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Autores principales: Garg, Rajat, Khan, Uqba, AlRajjal, Ahmed, Kafri, Zyad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731104/
https://www.ncbi.nlm.nih.gov/pubmed/29282390
http://dx.doi.org/10.1159/000484131
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author Garg, Rajat
Khan, Uqba
AlRajjal, Ahmed
Kafri, Zyad
author_facet Garg, Rajat
Khan, Uqba
AlRajjal, Ahmed
Kafri, Zyad
author_sort Garg, Rajat
collection PubMed
description Cholangiocarcinoma (CCA) is a very aggressive and lethal tumor, which arises from the epithelial cells of bile ducts. CCA comprises about 3% of all gastrointestinal malignancies and its incidence is on the rise in the recent years. Anatomically, it is classified into intrahepatic, perihilar, or extrahepatic (distal) CCA. There are a number of risk factors associated with CCA including primary sclerosing cholangitis, fibropolycystic liver disease, parasitic infection, viral hepatitis, chronic liver disease, and genetic disorders like Lynch syndrome. Autoimmune hepatitis is also recently reported to have an association with development of CCA. We report an interesting case of perihilar CCA in the setting of autoimmune hepatitis along with a literature review. This case highlights the importance of early treatment and close clinical follow-up of patients with autoimmune hepatitis for development of CCA.
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spelling pubmed-57311042017-12-27 Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma Garg, Rajat Khan, Uqba AlRajjal, Ahmed Kafri, Zyad Case Rep Gastroenterol Case and Review Cholangiocarcinoma (CCA) is a very aggressive and lethal tumor, which arises from the epithelial cells of bile ducts. CCA comprises about 3% of all gastrointestinal malignancies and its incidence is on the rise in the recent years. Anatomically, it is classified into intrahepatic, perihilar, or extrahepatic (distal) CCA. There are a number of risk factors associated with CCA including primary sclerosing cholangitis, fibropolycystic liver disease, parasitic infection, viral hepatitis, chronic liver disease, and genetic disorders like Lynch syndrome. Autoimmune hepatitis is also recently reported to have an association with development of CCA. We report an interesting case of perihilar CCA in the setting of autoimmune hepatitis along with a literature review. This case highlights the importance of early treatment and close clinical follow-up of patients with autoimmune hepatitis for development of CCA. S. Karger AG 2017-11-09 /pmc/articles/PMC5731104/ /pubmed/29282390 http://dx.doi.org/10.1159/000484131 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case and Review
Garg, Rajat
Khan, Uqba
AlRajjal, Ahmed
Kafri, Zyad
Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title_full Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title_fullStr Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title_full_unstemmed Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title_short Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma
title_sort autoimmune hepatitis: a risk factor for cholangiocarcinoma
topic Case and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731104/
https://www.ncbi.nlm.nih.gov/pubmed/29282390
http://dx.doi.org/10.1159/000484131
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AT kafrizyad autoimmunehepatitisariskfactorforcholangiocarcinoma