Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

Cancer drug screening in patient‐derived cells holds great promise for personalized oncology and drug discovery but lacks standardization. Whether cells are cultured as conventional monolayer or advanced, matrix‐dependent organoid cultures influences drug effects and thereby drug selection and clini...

Descripción completa

Detalles Bibliográficos
Autores principales: Jabs, Julia, Zickgraf, Franziska M, Park, Jeongbin, Wagner, Steve, Jiang, Xiaoqi, Jechow, Katharina, Kleinheinz, Kortine, Toprak, Umut H, Schneider, Marc A, Meister, Michael, Spaich, Saskia, Sütterlin, Marc, Schlesner, Matthias, Trumpp, Andreas, Sprick, Martin, Eils, Roland, Conrad, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731348/
https://www.ncbi.nlm.nih.gov/pubmed/29180611
http://dx.doi.org/10.15252/msb.20177697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731348/
https://www.ncbi.nlm.nih.gov/pubmed/29180611
http://dx.doi.org/10.15252/msb.20177697

Ejemplares similares