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Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria

BACKGROUND: Hypertensive heart failure (HHF) is the commonest form of heart failure in Nigeria. There is paucity of data in Nigeria on 24-hour Holter electrocardiography (24-HHECG) and important predictors of arrhythmias among HHF patients. OBJECTIVES: To determine the 24-HHECG characteristics among...

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Autores principales: Mene-Afejuku, Tuoyo Omasan, Balogun, Michael Olabode, Akintomide, Anthony Olubunmi, Adebayo, Rasaaq Ayodele, Ajayi, Olufemi Eyitayo, Amadi, Valentine N, Oketona, Omolola Abiodun, Ikwu, Amanze Nkemjika, Mene-Afejuku, Bamidele, Bamikole, Olaniyi James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731613/
https://www.ncbi.nlm.nih.gov/pubmed/29270037
http://dx.doi.org/10.1177/1179546817746632
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author Mene-Afejuku, Tuoyo Omasan
Balogun, Michael Olabode
Akintomide, Anthony Olubunmi
Adebayo, Rasaaq Ayodele
Ajayi, Olufemi Eyitayo
Amadi, Valentine N
Oketona, Omolola Abiodun
Ikwu, Amanze Nkemjika
Mene-Afejuku, Bamidele
Bamikole, Olaniyi James
author_facet Mene-Afejuku, Tuoyo Omasan
Balogun, Michael Olabode
Akintomide, Anthony Olubunmi
Adebayo, Rasaaq Ayodele
Ajayi, Olufemi Eyitayo
Amadi, Valentine N
Oketona, Omolola Abiodun
Ikwu, Amanze Nkemjika
Mene-Afejuku, Bamidele
Bamikole, Olaniyi James
author_sort Mene-Afejuku, Tuoyo Omasan
collection PubMed
description BACKGROUND: Hypertensive heart failure (HHF) is the commonest form of heart failure in Nigeria. There is paucity of data in Nigeria on 24-hour Holter electrocardiography (24-HHECG) and important predictors of arrhythmias among HHF patients. OBJECTIVES: To determine the 24-HHECG characteristics among HHF patients. To determine the clinical and echocardiographic predictors of arrhythmias detected using 24-HHECG among HHF patients. METHODS: A total of 100 HHF patients as well as 50 age-matched and sex-matched apparently healthy controls were prospectively recruited over a period of 1 year. They all had baseline laboratory tests, echocardiography, and 24-HHECG. RESULTS: Hypertensive heart failure patients had significantly higher counts of premature ventricular contractions (PVCs) than the controls (P ≤ .001). Ventricular tachycardia (VT) was recorded in 29% of HHF patients as compared with controls who had no VT on 24-HHECG. The standard deviation of all normal to normal sinus RR intervals over 24 hours (SDNN) was abnormally reduced among HHF patients when compared with controls (P = .046). There was positive correlation between atrial fibrillation (AF) and the following parameters: PVCs (r = .229, P = .015), New York Heart Association (NYHA) (r = .196, P = .033), and VT (r = .223, P = .018). Following multiple linear regression, left ventricular ejection fraction (LVEF) (P ≤ .001) and serum urea (P = .037) were predictors of PVCs among HHF patients. Serum creatinine (P ≤ .001), elevated systolic blood pressure (SBP) (P = .005), and PVCs (P ≤ .001) were important predictors of VT among HHF patients. CONCLUSIONS: Renal dysfunction and reduced LVEF were important predictors of ventricular arrhythmias. High counts of PVCs and elevated SBP were predictive of the occurrence of VT among HHF patients. The NYHA class and ventricular arrhythmias have a significant positive correlation with AF. The SDNN is reduced in HHF patients.
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spelling pubmed-57316132017-12-21 Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria Mene-Afejuku, Tuoyo Omasan Balogun, Michael Olabode Akintomide, Anthony Olubunmi Adebayo, Rasaaq Ayodele Ajayi, Olufemi Eyitayo Amadi, Valentine N Oketona, Omolola Abiodun Ikwu, Amanze Nkemjika Mene-Afejuku, Bamidele Bamikole, Olaniyi James Clin Med Insights Cardiol Original Research BACKGROUND: Hypertensive heart failure (HHF) is the commonest form of heart failure in Nigeria. There is paucity of data in Nigeria on 24-hour Holter electrocardiography (24-HHECG) and important predictors of arrhythmias among HHF patients. OBJECTIVES: To determine the 24-HHECG characteristics among HHF patients. To determine the clinical and echocardiographic predictors of arrhythmias detected using 24-HHECG among HHF patients. METHODS: A total of 100 HHF patients as well as 50 age-matched and sex-matched apparently healthy controls were prospectively recruited over a period of 1 year. They all had baseline laboratory tests, echocardiography, and 24-HHECG. RESULTS: Hypertensive heart failure patients had significantly higher counts of premature ventricular contractions (PVCs) than the controls (P ≤ .001). Ventricular tachycardia (VT) was recorded in 29% of HHF patients as compared with controls who had no VT on 24-HHECG. The standard deviation of all normal to normal sinus RR intervals over 24 hours (SDNN) was abnormally reduced among HHF patients when compared with controls (P = .046). There was positive correlation between atrial fibrillation (AF) and the following parameters: PVCs (r = .229, P = .015), New York Heart Association (NYHA) (r = .196, P = .033), and VT (r = .223, P = .018). Following multiple linear regression, left ventricular ejection fraction (LVEF) (P ≤ .001) and serum urea (P = .037) were predictors of PVCs among HHF patients. Serum creatinine (P ≤ .001), elevated systolic blood pressure (SBP) (P = .005), and PVCs (P ≤ .001) were important predictors of VT among HHF patients. CONCLUSIONS: Renal dysfunction and reduced LVEF were important predictors of ventricular arrhythmias. High counts of PVCs and elevated SBP were predictive of the occurrence of VT among HHF patients. The NYHA class and ventricular arrhythmias have a significant positive correlation with AF. The SDNN is reduced in HHF patients. SAGE Publications 2017-12-10 /pmc/articles/PMC5731613/ /pubmed/29270037 http://dx.doi.org/10.1177/1179546817746632 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Mene-Afejuku, Tuoyo Omasan
Balogun, Michael Olabode
Akintomide, Anthony Olubunmi
Adebayo, Rasaaq Ayodele
Ajayi, Olufemi Eyitayo
Amadi, Valentine N
Oketona, Omolola Abiodun
Ikwu, Amanze Nkemjika
Mene-Afejuku, Bamidele
Bamikole, Olaniyi James
Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title_full Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title_fullStr Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title_full_unstemmed Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title_short Clinical and Echocardiographic Predictors of Arrhythmias Detected With 24-Hour Holter Electrocardiography Among Hypertensive Heart Failure Patients in Nigeria
title_sort clinical and echocardiographic predictors of arrhythmias detected with 24-hour holter electrocardiography among hypertensive heart failure patients in nigeria
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731613/
https://www.ncbi.nlm.nih.gov/pubmed/29270037
http://dx.doi.org/10.1177/1179546817746632
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