Identity crisis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity cris...

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Detalles Bibliográficos
Autores principales: Ruffenach, G., Bonnet, S., Rousseaux, S., Khochbin, S., Provencher, S., Perros, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731718/
https://www.ncbi.nlm.nih.gov/pubmed/29206084
http://dx.doi.org/10.1177/2045893217746054
Descripción
Sumario:Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.

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