Identity crisis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity cris...

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Detalles Bibliográficos
Autores principales: Ruffenach, G., Bonnet, S., Rousseaux, S., Khochbin, S., Provencher, S., Perros, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731718/
https://www.ncbi.nlm.nih.gov/pubmed/29206084
http://dx.doi.org/10.1177/2045893217746054
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author Ruffenach, G.
Bonnet, S.
Rousseaux, S.
Khochbin, S.
Provencher, S.
Perros, F.
author_facet Ruffenach, G.
Bonnet, S.
Rousseaux, S.
Khochbin, S.
Provencher, S.
Perros, F.
author_sort Ruffenach, G.
collection PubMed
description Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.
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spelling pubmed-57317182018-01-09 Identity crisis in pulmonary arterial hypertension Ruffenach, G. Bonnet, S. Rousseaux, S. Khochbin, S. Provencher, S. Perros, F. Pulm Circ Research Letter Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes. SAGE Publications 2017-12-05 /pmc/articles/PMC5731718/ /pubmed/29206084 http://dx.doi.org/10.1177/2045893217746054 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Ruffenach, G.
Bonnet, S.
Rousseaux, S.
Khochbin, S.
Provencher, S.
Perros, F.
Identity crisis in pulmonary arterial hypertension
title Identity crisis in pulmonary arterial hypertension
title_full Identity crisis in pulmonary arterial hypertension
title_fullStr Identity crisis in pulmonary arterial hypertension
title_full_unstemmed Identity crisis in pulmonary arterial hypertension
title_short Identity crisis in pulmonary arterial hypertension
title_sort identity crisis in pulmonary arterial hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731718/
https://www.ncbi.nlm.nih.gov/pubmed/29206084
http://dx.doi.org/10.1177/2045893217746054
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