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Identity crisis in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity cris...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731718/ https://www.ncbi.nlm.nih.gov/pubmed/29206084 http://dx.doi.org/10.1177/2045893217746054 |
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author | Ruffenach, G. Bonnet, S. Rousseaux, S. Khochbin, S. Provencher, S. Perros, F. |
author_facet | Ruffenach, G. Bonnet, S. Rousseaux, S. Khochbin, S. Provencher, S. Perros, F. |
author_sort | Ruffenach, G. |
collection | PubMed |
description | Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes. |
format | Online Article Text |
id | pubmed-5731718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-57317182018-01-09 Identity crisis in pulmonary arterial hypertension Ruffenach, G. Bonnet, S. Rousseaux, S. Khochbin, S. Provencher, S. Perros, F. Pulm Circ Research Letter Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes. SAGE Publications 2017-12-05 /pmc/articles/PMC5731718/ /pubmed/29206084 http://dx.doi.org/10.1177/2045893217746054 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Letter Ruffenach, G. Bonnet, S. Rousseaux, S. Khochbin, S. Provencher, S. Perros, F. Identity crisis in pulmonary arterial hypertension |
title | Identity crisis in pulmonary arterial hypertension |
title_full | Identity crisis in pulmonary arterial hypertension |
title_fullStr | Identity crisis in pulmonary arterial hypertension |
title_full_unstemmed | Identity crisis in pulmonary arterial hypertension |
title_short | Identity crisis in pulmonary arterial hypertension |
title_sort | identity crisis in pulmonary arterial hypertension |
topic | Research Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731718/ https://www.ncbi.nlm.nih.gov/pubmed/29206084 http://dx.doi.org/10.1177/2045893217746054 |
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