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Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chr...
Autores principales: | de Groot, Theun, Damen, Lars, Kosse, Leanne, Alsady, Mohammad, Doty, Rosalinda, Baumgarten, Ruben, Sheehan, Susan, van der Vlag, Johan, Korstanje, Ron, Deen, Peter M. T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731748/ https://www.ncbi.nlm.nih.gov/pubmed/29244860 http://dx.doi.org/10.1371/journal.pone.0189485 |
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