Cargando…

Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

High fidelity replicative DNA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive oxygen species or UV light. To bypass these replication blocks, cells utilize specialized translesion DNA polymerases that are intrinsically error prone and associated wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Gengjing, Gleave, Emma S, Lamers, Meindert Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731819/ https://www.ncbi.nlm.nih.gov/pubmed/29210356 http://dx.doi.org/10.7554/eLife.32177

Ejemplares similares

Characterization of human translesion DNA synthesis across a UV-induced DNA lesion
por: Hedglin, Mark, et al.
Publicado: (2016)

Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome
por: Gessner, Sophia, et al.
Publicado: (2023)

Molecular determinants of phase separation for Drosophila DNA replication licensing factors
por: Parker, Matthew W, et al.
Publicado: (2021)

A new class of disordered elements controls DNA replication through initiator self-assembly
por: Parker, Matthew W, et al.
Publicado: (2019)

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway
por: Chim, Nicholas, et al.
Publicado: (2018)

Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs
por: Srinivasan, Madhusudhan, et al.
Publicado: (2020)

Mechanisms of opening and closing of the bacterial replicative helicase
por: Chase, Jillian, et al.
Publicado: (2018)

Visualizing molecules of functional human profilin
por: Pimm, Morgan L, et al.
Publicado: (2022)

Ctf4 organizes sister replisomes and Pol α into a replication factory
por: Yuan, Zuanning, et al.
Publicado: (2019)

Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53
por: Abd Wahab, Syafiq, et al.
Publicado: (2020)

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules
por: Hagenbuchner, Judith, et al.
Publicado: (2019)

Bayesian machine learning analysis of single-molecule fluorescence colocalization images
por: Ordabayev, Yerdos A, et al.
Publicado: (2022)

Single-molecule analysis of the entire perfringolysin O pore formation pathway
por: McGuinness, Conall, et al.
Publicado: (2022)

Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers
por: Choi, Byoungsan, et al.
Publicado: (2020)

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
por: Woody, Michael S, et al.
Publicado: (2019)

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
por: Ruiz, E Josue, et al.
Publicado: (2021)

Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery
por: Ngan, Kevin Chun-Ho, et al.
Publicado: (2023)

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
por: Smith, Quentin M, et al.
Publicado: (2021)

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
por: Amberg-Johnson, Katherine, et al.
Publicado: (2017)

Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells
por: Deveryshetty, Jaigeeth, et al.
Publicado: (2019)

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
por: Paudel, Bishnu P, et al.
Publicado: (2020)

Rolling circle RNA synthesis catalyzed by RNA
por: Kristoffersen, Emil Laust, et al.
Publicado: (2022)

Membrane-partitioned cell wall synthesis in mycobacteria
por: García-Heredia, Alam, et al.
Publicado: (2021)

Getting ready for DNA duplication
por: Yao, Nina Y, et al.
Publicado: (2019)

Translesion-synthesis DNA polymerases participate in replication of the telomeres in Streptomyces
por: Tsai, Hsiu-Hui, et al.
Publicado: (2012)

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ
por: Hirota, Kouji, et al.
Publicado: (2016)

Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases
por: Baruch-Torres, Noe, et al.
Publicado: (2017)

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
por: Wong, Yao Liang, et al.
Publicado: (2018)

Direct visualization of translesion DNA synthesis polymerase IV at the replisome
por: Tuan, Pham Minh, et al.
Publicado: (2022)

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks
por: Langston, Lance D, et al.
Publicado: (2017)

Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
por: Paul, Maarten W, et al.
Publicado: (2021)

Transitioning to DNA genomes in an RNA world
por: Cojocaru, Razvan, et al.
Publicado: (2017)

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response
por: Lin, Yunfeng, et al.
Publicado: (2023)

Ribozyme-catalysed RNA synthesis using triplet building blocks
por: Attwater, James, et al.
Publicado: (2018)

Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria
por: García-Heredia, Alam, et al.
Publicado: (2018)

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice
por: Meng, Fanbiao, et al.
Publicado: (2020)

Cryo-EM structures reveal that RFC recognizes both the 3′- and 5′-DNA ends to load PCNA onto gaps for DNA repair
por: Zheng, Fengwei, et al.
Publicado: (2022)

Control of cyclic oligoadenylate synthesis in a type III CRISPR system
por: Rouillon, Christophe, et al.
Publicado: (2018)

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
por: Nowinski, Sara M, et al.
Publicado: (2020)

Transposase-assisted tagmentation of RNA/DNA hybrid duplexes
por: Lu, Bo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qt8cpkafpluh36b7qj1h5lv4a9