LC-MS-based metabolomics revealed SLC25A22 as an essential regulator of aspartate-derived amino acids and polyamines in KRAS-mutant colorectal cancer

SLC25A22, which encodes the mitochondrial glutamate transporter, is overexpressed in colorectal cancer (CRC) and is essential for the proliferation of CRC cells harboring KRAS mutations. However, the role of SLC25A22 on metabolic regulation in KRAS-mutant CRC cells has not been comprehensively chara...

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Detalles Bibliográficos
Autores principales: Li, Xiaona, Chung, Arthur C.K., Li, Shangfu, Wu, Lilan, Xu, Jiaying, Yu, Jun, Wong, Chichun, Cai, Zongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731878/
https://www.ncbi.nlm.nih.gov/pubmed/29254168
http://dx.doi.org/10.18632/oncotarget.21093

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