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NOD2 maybe a biomarker for the survival of kidney cancer patients
BACKGROUND: Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) may play an important role in the outcome of kidney cancer patients. To explore the relationship between NOD2 and the prognosis of kidney cancer patients, a databank-based reanalysis was conducted. MATERIALS AND METHOD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731890/ https://www.ncbi.nlm.nih.gov/pubmed/29254180 http://dx.doi.org/10.18632/oncotarget.21547 |
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author | Xu, Deguo Zhang, Shuisheng Zhang, Shenfeng Liu, Hongmei Li, Paiyun Yu, Lili Shang, Heli Hou, Yong Tian, Yuan |
author_facet | Xu, Deguo Zhang, Shuisheng Zhang, Shenfeng Liu, Hongmei Li, Paiyun Yu, Lili Shang, Heli Hou, Yong Tian, Yuan |
author_sort | Xu, Deguo |
collection | PubMed |
description | BACKGROUND: Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) may play an important role in the outcome of kidney cancer patients. To explore the relationship between NOD2 and the prognosis of kidney cancer patients, a databank-based reanalysis was conducted. MATERIALS AND METHODS: Data related to kidney cancer patients at least with survival information, was obtained mainly from The Cancer Genome Atlas (TCGA). Some clinical data, not available online, was collected by personal email to the author. Then, we reanalyzed all the data in order to make a conclusion about the relationship between NOD2 gene and the prognosis of kidney cancer patients. RESULTS: A total of 1953 samples with NOD2 information from four databanks of The Cancer Genome Atlas (TCGA) were enrolled in this study. The results of KIPAN showed the Kaplan-Meier curve for risk groups, concordance index, and p-value of the log-rank testing equality of survival curves ( Concordance Index = 56.57, Log−Rank Equal Curves p=0.0009006, R^2 = 0.036/0.953, Risk Groups Hazard Ratio = 1.61 (conf. int. 1.21 ~ 2.13), p = 0.001005) , while a box plot across risk groups, including the p-value testing for difference using t-test (or f-test for more than two groups) was shown. There was a statistical significance for the p value of the result (p < 0.01 ). The similar results could be seen in KIRC and the fourth data (including 468 samples). CONCLUSIONS: The status of NOD2 gene maybe a biomarker for the survival of kidney cancer patients. |
format | Online Article Text |
id | pubmed-5731890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57318902017-12-17 NOD2 maybe a biomarker for the survival of kidney cancer patients Xu, Deguo Zhang, Shuisheng Zhang, Shenfeng Liu, Hongmei Li, Paiyun Yu, Lili Shang, Heli Hou, Yong Tian, Yuan Oncotarget Research Paper BACKGROUND: Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) may play an important role in the outcome of kidney cancer patients. To explore the relationship between NOD2 and the prognosis of kidney cancer patients, a databank-based reanalysis was conducted. MATERIALS AND METHODS: Data related to kidney cancer patients at least with survival information, was obtained mainly from The Cancer Genome Atlas (TCGA). Some clinical data, not available online, was collected by personal email to the author. Then, we reanalyzed all the data in order to make a conclusion about the relationship between NOD2 gene and the prognosis of kidney cancer patients. RESULTS: A total of 1953 samples with NOD2 information from four databanks of The Cancer Genome Atlas (TCGA) were enrolled in this study. The results of KIPAN showed the Kaplan-Meier curve for risk groups, concordance index, and p-value of the log-rank testing equality of survival curves ( Concordance Index = 56.57, Log−Rank Equal Curves p=0.0009006, R^2 = 0.036/0.953, Risk Groups Hazard Ratio = 1.61 (conf. int. 1.21 ~ 2.13), p = 0.001005) , while a box plot across risk groups, including the p-value testing for difference using t-test (or f-test for more than two groups) was shown. There was a statistical significance for the p value of the result (p < 0.01 ). The similar results could be seen in KIRC and the fourth data (including 468 samples). CONCLUSIONS: The status of NOD2 gene maybe a biomarker for the survival of kidney cancer patients. Impact Journals LLC 2017-10-06 /pmc/articles/PMC5731890/ /pubmed/29254180 http://dx.doi.org/10.18632/oncotarget.21547 Text en Copyright: © 2017 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xu, Deguo Zhang, Shuisheng Zhang, Shenfeng Liu, Hongmei Li, Paiyun Yu, Lili Shang, Heli Hou, Yong Tian, Yuan NOD2 maybe a biomarker for the survival of kidney cancer patients |
title | NOD2 maybe a biomarker for the survival of kidney cancer patients |
title_full | NOD2 maybe a biomarker for the survival of kidney cancer patients |
title_fullStr | NOD2 maybe a biomarker for the survival of kidney cancer patients |
title_full_unstemmed | NOD2 maybe a biomarker for the survival of kidney cancer patients |
title_short | NOD2 maybe a biomarker for the survival of kidney cancer patients |
title_sort | nod2 maybe a biomarker for the survival of kidney cancer patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731890/ https://www.ncbi.nlm.nih.gov/pubmed/29254180 http://dx.doi.org/10.18632/oncotarget.21547 |
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