VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim

The PI3K/mTOR/AKT pathway is an integral regulator of survival and drug resistance in multiple myeloma (MM). VS-5584 was synthesized with dual-specific and equipotent activity against mTORC1/2 and all four Class I PI3K isoforms so as to durably inhibit this pathway. We show that VS-5584 is highly ef...

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Detalles Bibliográficos
Autores principales: Mustafa, Nurulhuda, Ting Lee, Jeannie Xue, Adina Nee, Huey Fang, Bi, Chonglei, Chung, Tae-Hoon, Hart, Stefan, Chng, Wee Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731918/
https://www.ncbi.nlm.nih.gov/pubmed/29254208
http://dx.doi.org/10.18632/oncotarget.21988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731918/
https://www.ncbi.nlm.nih.gov/pubmed/29254208
http://dx.doi.org/10.18632/oncotarget.21988

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