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Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities

Our recent study showed that acute myeloid leukemia (AML) cells expressing SULT1A1 are highly sensitive to NSC-743380, a small molecule that inhibits STAT3 activity and induces SULT1A1-dependent apoptosis of various cancer cell lines. In this study, we characterized the molecular mechanisms of NSC-7...

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Detalles Bibliográficos
Autores principales:	Huang, Xiao, Cao, Mengru, Wu, Shuhong, Wang, Li, Hu, Jing, Mehran, Reza J., Roth, Jack A., Swisher, Stephen G., Wang, Rui-Yu, Kantarjian, Hagop M., Andreeff, Michael, Sun, Xiaoping, Fang, Bingliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731942/ https://www.ncbi.nlm.nih.gov/pubmed/29254232 http://dx.doi.org/10.18632/oncotarget.22235

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