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A core program of gene expression characterizes cancer metastases
While aberrant expression or splicing of metastasis genes conveys to cancers the ability to break through tissue barriers and disseminate, the genetic basis for organ preference in metastasis formation has remained incompletely understood. Utilizing the gene expression profiles from 653 GEO datasets...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731943/ https://www.ncbi.nlm.nih.gov/pubmed/29254233 http://dx.doi.org/10.18632/oncotarget.22240 |
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author | Hartung, Franz Wang, Yunguan Aronow, Bruce Weber, Georg F. |
author_facet | Hartung, Franz Wang, Yunguan Aronow, Bruce Weber, Georg F. |
author_sort | Hartung, Franz |
collection | PubMed |
description | While aberrant expression or splicing of metastasis genes conveys to cancers the ability to break through tissue barriers and disseminate, the genetic basis for organ preference in metastasis formation has remained incompletely understood. Utilizing the gene expression profiles from 653 GEO datasets, we investigate whether the signatures by diverse cancers in various metastatic sites display common features. We corroborate the meta-analysis in a murine model. Metastases are generally characterized by a core program of gene expression that induces the oxidative metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This program distinguishes metastases from their originating primary tumors as well as from their target host tissues. Site-selectivity is accomplished through specific components that adjust to the target micro-environment. The same functional groups of gene expression programs are activated in the metastases of B16-F10 cells to various target organs. It remains to be investigated whether these genetic signatures precede implantation and thus determine organ preference or are shaped by the target site and are thus a consequence of implantation. Conceivably, chemotherapy of disseminated cancer might be more efficacious if selected to match the genetic makeup of the metastases rather than the organ of origin by the primary tumor. |
format | Online Article Text |
id | pubmed-5731943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57319432017-12-17 A core program of gene expression characterizes cancer metastases Hartung, Franz Wang, Yunguan Aronow, Bruce Weber, Georg F. Oncotarget Research Paper While aberrant expression or splicing of metastasis genes conveys to cancers the ability to break through tissue barriers and disseminate, the genetic basis for organ preference in metastasis formation has remained incompletely understood. Utilizing the gene expression profiles from 653 GEO datasets, we investigate whether the signatures by diverse cancers in various metastatic sites display common features. We corroborate the meta-analysis in a murine model. Metastases are generally characterized by a core program of gene expression that induces the oxidative metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This program distinguishes metastases from their originating primary tumors as well as from their target host tissues. Site-selectivity is accomplished through specific components that adjust to the target micro-environment. The same functional groups of gene expression programs are activated in the metastases of B16-F10 cells to various target organs. It remains to be investigated whether these genetic signatures precede implantation and thus determine organ preference or are shaped by the target site and are thus a consequence of implantation. Conceivably, chemotherapy of disseminated cancer might be more efficacious if selected to match the genetic makeup of the metastases rather than the organ of origin by the primary tumor. Impact Journals LLC 2017-11-02 /pmc/articles/PMC5731943/ /pubmed/29254233 http://dx.doi.org/10.18632/oncotarget.22240 Text en Copyright: © 2017 Hartung et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Hartung, Franz Wang, Yunguan Aronow, Bruce Weber, Georg F. A core program of gene expression characterizes cancer metastases |
title | A core program of gene expression characterizes cancer metastases |
title_full | A core program of gene expression characterizes cancer metastases |
title_fullStr | A core program of gene expression characterizes cancer metastases |
title_full_unstemmed | A core program of gene expression characterizes cancer metastases |
title_short | A core program of gene expression characterizes cancer metastases |
title_sort | core program of gene expression characterizes cancer metastases |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731943/ https://www.ncbi.nlm.nih.gov/pubmed/29254233 http://dx.doi.org/10.18632/oncotarget.22240 |
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