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Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract

The cytosolic calcium ([Ca(2+)]cyt) is one of the most important cell signaling that can modulate gastrointestinal (GI) epithelial secretion and promote GI mucosal wound repair. The GI mucosal bicarbonate secretion is the main mechanism of mucosal protection. Our research team has been working in th...

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Detalles Bibliográficos
Autores principales: He, Jialin, Yang, Xin, Guo, Yanjun, Zhang, Fenglian, Wan, Hanxing, Sun, Xuemei, Tuo, Biguang, Dong, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731990/
https://www.ncbi.nlm.nih.gov/pubmed/29254280
http://dx.doi.org/10.18632/oncotarget.21840
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author He, Jialin
Yang, Xin
Guo, Yanjun
Zhang, Fenglian
Wan, Hanxing
Sun, Xuemei
Tuo, Biguang
Dong, Hui
author_facet He, Jialin
Yang, Xin
Guo, Yanjun
Zhang, Fenglian
Wan, Hanxing
Sun, Xuemei
Tuo, Biguang
Dong, Hui
author_sort He, Jialin
collection PubMed
description The cytosolic calcium ([Ca(2+)]cyt) is one of the most important cell signaling that can modulate gastrointestinal (GI) epithelial secretion and promote GI mucosal wound repair. The GI mucosal bicarbonate secretion is the main mechanism of mucosal protection. Our research team has been working in this field and provided solid evidence for the important role of Ca(2+) signaling in the regulation of GI epithelial secretion and the underlying molecular mechanisms. In this review, we attempt to systemically review the current status of our knowledge on the role of Ca(2+) signaling in the regulation of intestinal bicarbonate secretion and in the upper GI epithelial protection. We expect that novel targets could be identified for drug development to better protect GI mucosa and treat mucosal injury with the advance in this filed.
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spelling pubmed-57319902017-12-17 Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract He, Jialin Yang, Xin Guo, Yanjun Zhang, Fenglian Wan, Hanxing Sun, Xuemei Tuo, Biguang Dong, Hui Oncotarget Review The cytosolic calcium ([Ca(2+)]cyt) is one of the most important cell signaling that can modulate gastrointestinal (GI) epithelial secretion and promote GI mucosal wound repair. The GI mucosal bicarbonate secretion is the main mechanism of mucosal protection. Our research team has been working in this field and provided solid evidence for the important role of Ca(2+) signaling in the regulation of GI epithelial secretion and the underlying molecular mechanisms. In this review, we attempt to systemically review the current status of our knowledge on the role of Ca(2+) signaling in the regulation of intestinal bicarbonate secretion and in the upper GI epithelial protection. We expect that novel targets could be identified for drug development to better protect GI mucosa and treat mucosal injury with the advance in this filed. Impact Journals LLC 2017-10-12 /pmc/articles/PMC5731990/ /pubmed/29254280 http://dx.doi.org/10.18632/oncotarget.21840 Text en Copyright: © 2017 He et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
He, Jialin
Yang, Xin
Guo, Yanjun
Zhang, Fenglian
Wan, Hanxing
Sun, Xuemei
Tuo, Biguang
Dong, Hui
Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title_full Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title_fullStr Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title_full_unstemmed Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title_short Ca(2+) signaling in HCO(3)(−) secretion and protection of upper GI tract
title_sort ca(2+) signaling in hco(3)(−) secretion and protection of upper gi tract
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731990/
https://www.ncbi.nlm.nih.gov/pubmed/29254280
http://dx.doi.org/10.18632/oncotarget.21840
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