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Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS

OBJECTIVE: To investigate primary retinal functional changes in non-optic neuritis (ON) eyes of patients with MS by full-field electroretinography (ERG). METHODS: Seventy-seven patients with relapsing-remitting MS with no history of clinical ON in at least 1 eye and 30 healthy controls were recruite...

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Autores principales: You, Yuyi, Graham, Elizabeth C., Shen, Ting, Yiannikas, Con, Parratt, John, Gupta, Vivek, Barton, Joshua, Dwyer, Michael, Barnett, Michael H., Fraser, Clare L., Graham, Stuart L., Klistorner, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732006/
https://www.ncbi.nlm.nih.gov/pubmed/29259999
http://dx.doi.org/10.1212/NXI.0000000000000427
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author You, Yuyi
Graham, Elizabeth C.
Shen, Ting
Yiannikas, Con
Parratt, John
Gupta, Vivek
Barton, Joshua
Dwyer, Michael
Barnett, Michael H.
Fraser, Clare L.
Graham, Stuart L.
Klistorner, Alexander
author_facet You, Yuyi
Graham, Elizabeth C.
Shen, Ting
Yiannikas, Con
Parratt, John
Gupta, Vivek
Barton, Joshua
Dwyer, Michael
Barnett, Michael H.
Fraser, Clare L.
Graham, Stuart L.
Klistorner, Alexander
author_sort You, Yuyi
collection PubMed
description OBJECTIVE: To investigate primary retinal functional changes in non-optic neuritis (ON) eyes of patients with MS by full-field electroretinography (ERG). METHODS: Seventy-seven patients with relapsing-remitting MS with no history of clinical ON in at least 1 eye and 30 healthy controls were recruited in the cohort study. Full-field ERGs were recorded, and retinal optical coherence tomography scans were performed to assess the thicknesses of peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell layer–inner plexiform layer (GCL-IPL). Annual MRI scans were also carried out to evaluate the disease activity in the brain. Patients were followed up for 3 years. RESULTS: At baseline, a delayed b-wave peak time was observed in the cone response (p < 0.001), which was associated with the thicknesses of RNFL and GCL-IPL. The peak time of the delayed b-wave also correlated with the Expanded Disability Status Scale, T2 lesion volume, and disease duration. During the 3-year follow-up, progressive ERG amplitude reduction was observed (both a- and b-waves, p < 0.05). There was a correlation between the b-wave amplitude reduction and longitudinal RNFL loss (p = 0.001). However, no correlation was found between longitudinal ERG changes and disease activity in the brain. CONCLUSIONS: This study demonstrated progressive inner nuclear layer dysfunction in MS. The borderline a-wave changes suggested some outer retinal dysfunction as well. The correlation between full-field ERG changes and retinal ganglion cell loss suggested that there might be subclinical retinal pathology in MS affecting both outer and inner retinal layers.
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spelling pubmed-57320062017-12-19 Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS You, Yuyi Graham, Elizabeth C. Shen, Ting Yiannikas, Con Parratt, John Gupta, Vivek Barton, Joshua Dwyer, Michael Barnett, Michael H. Fraser, Clare L. Graham, Stuart L. Klistorner, Alexander Neurol Neuroimmunol Neuroinflamm Article OBJECTIVE: To investigate primary retinal functional changes in non-optic neuritis (ON) eyes of patients with MS by full-field electroretinography (ERG). METHODS: Seventy-seven patients with relapsing-remitting MS with no history of clinical ON in at least 1 eye and 30 healthy controls were recruited in the cohort study. Full-field ERGs were recorded, and retinal optical coherence tomography scans were performed to assess the thicknesses of peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell layer–inner plexiform layer (GCL-IPL). Annual MRI scans were also carried out to evaluate the disease activity in the brain. Patients were followed up for 3 years. RESULTS: At baseline, a delayed b-wave peak time was observed in the cone response (p < 0.001), which was associated with the thicknesses of RNFL and GCL-IPL. The peak time of the delayed b-wave also correlated with the Expanded Disability Status Scale, T2 lesion volume, and disease duration. During the 3-year follow-up, progressive ERG amplitude reduction was observed (both a- and b-waves, p < 0.05). There was a correlation between the b-wave amplitude reduction and longitudinal RNFL loss (p = 0.001). However, no correlation was found between longitudinal ERG changes and disease activity in the brain. CONCLUSIONS: This study demonstrated progressive inner nuclear layer dysfunction in MS. The borderline a-wave changes suggested some outer retinal dysfunction as well. The correlation between full-field ERG changes and retinal ganglion cell loss suggested that there might be subclinical retinal pathology in MS affecting both outer and inner retinal layers. Lippincott Williams & Wilkins 2017-12-15 /pmc/articles/PMC5732006/ /pubmed/29259999 http://dx.doi.org/10.1212/NXI.0000000000000427 Text en Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
You, Yuyi
Graham, Elizabeth C.
Shen, Ting
Yiannikas, Con
Parratt, John
Gupta, Vivek
Barton, Joshua
Dwyer, Michael
Barnett, Michael H.
Fraser, Clare L.
Graham, Stuart L.
Klistorner, Alexander
Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title_full Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title_fullStr Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title_full_unstemmed Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title_short Progressive inner nuclear layer dysfunction in non-optic neuritis eyes in MS
title_sort progressive inner nuclear layer dysfunction in non-optic neuritis eyes in ms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732006/
https://www.ncbi.nlm.nih.gov/pubmed/29259999
http://dx.doi.org/10.1212/NXI.0000000000000427
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