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Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function. CAPS is a systemic auto-inflammatory syndrome characterized by the activation of the innate immune system induced by elevated pro-inflammatory cytok...

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Detalles Bibliográficos
Autores principales:	Johnson, Jennifer L., Ramadass, Mahalakshmi, Haimovich, Ariela, McGeough, Matthew D., Zhang, Jinzhong, Hoffman, Hal M., Catz, Sergio D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732154/ https://www.ncbi.nlm.nih.gov/pubmed/29322034 http://dx.doi.org/10.3389/fcimb.2017.00507

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