Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and reviv...

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Autores principales: Sharma, Divakar, Dhuriya, Yogesh K., Deo, Nirmala, Bisht, Deepa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732208/
https://www.ncbi.nlm.nih.gov/pubmed/29321768
http://dx.doi.org/10.3389/fmicb.2017.02452
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author Sharma, Divakar
Dhuriya, Yogesh K.
Deo, Nirmala
Bisht, Deepa
author_facet Sharma, Divakar
Dhuriya, Yogesh K.
Deo, Nirmala
Bisht, Deepa
author_sort Sharma, Divakar
collection PubMed
description Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in the antibiotics resistance era or in the situation of global emergency. Bactericidal and synergistic effect of repurposed/revived drugs along with the latest drugs bedaquiline and delamanid used in the treatment of MDR-TB, XDR-TB, and TDR-TB might be the choice for future promising combinatorial chemotherapy against these bad bugs.
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spelling pubmed-57322082018-01-10 Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis Sharma, Divakar Dhuriya, Yogesh K. Deo, Nirmala Bisht, Deepa Front Microbiol Microbiology Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of Mycobacterium tuberculosis. Repurposing and revival of the drugs are the new trends/options to combat these worsen situations of tuberculosis in the antibiotics resistance era or in the situation of global emergency. Bactericidal and synergistic effect of repurposed/revived drugs along with the latest drugs bedaquiline and delamanid used in the treatment of MDR-TB, XDR-TB, and TDR-TB might be the choice for future promising combinatorial chemotherapy against these bad bugs. Frontiers Media S.A. 2017-12-11 /pmc/articles/PMC5732208/ /pubmed/29321768 http://dx.doi.org/10.3389/fmicb.2017.02452 Text en Copyright © 2017 Sharma, Dhuriya, Deo and Bisht. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Sharma, Divakar
Dhuriya, Yogesh K.
Deo, Nirmala
Bisht, Deepa
Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title_full Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title_fullStr Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title_full_unstemmed Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title_short Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis
title_sort repurposing and revival of the drugs: a new approach to combat the drug resistant tuberculosis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732208/
https://www.ncbi.nlm.nih.gov/pubmed/29321768
http://dx.doi.org/10.3389/fmicb.2017.02452
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