Cargando…
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
T cells can recognize peptides encoded by mutated genes, but analysis of tumor-infiltrating lymphocytes suggests that very few neoantigens spontaneously elicit T-cell responses. This may be an important reason why immune checkpoint inhibitors are mainly effective in tumors with a high mutational bur...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732232/ https://www.ncbi.nlm.nih.gov/pubmed/29321773 http://dx.doi.org/10.3389/fimmu.2017.01718 |