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Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome
Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongs...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732272/ https://www.ncbi.nlm.nih.gov/pubmed/29247200 http://dx.doi.org/10.1038/s41598-017-17710-6 |
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author | Mahbub, MH Yamaguchi, Natsu Takahashi, Hidekazu Hase, Ryosuke Ishimaru, Yasutaka Sunagawa, Hiroshi Amano, Hiroki Kobayashi-Miura, Mikiko Kanda, Hideyuki Fujita, Yasuyuki Yamamoto, Hiroshi Yamamoto, Mai Kikuchi, Shinya Ikeda, Atsuko Kageyama, Naoko Nakamura, Mina Tanabe, Tsuyoshi |
author_facet | Mahbub, MH Yamaguchi, Natsu Takahashi, Hidekazu Hase, Ryosuke Ishimaru, Yasutaka Sunagawa, Hiroshi Amano, Hiroki Kobayashi-Miura, Mikiko Kanda, Hideyuki Fujita, Yasuyuki Yamamoto, Hiroshi Yamamoto, Mai Kikuchi, Shinya Ikeda, Atsuko Kageyama, Naoko Nakamura, Mina Tanabe, Tsuyoshi |
author_sort | Mahbub, MH |
collection | PubMed |
description | Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects without LSRDs (no-LSRD, n = 2805), and with diabetes mellitus (DM, n = 415), dyslipidemia (n = 3207), hypertension (n = 2736) and metabolic syndrome (MetS, n = 717). The concentrations of most amino acids differed significantly between the subjects with and without hyperuricemia (HU) and also between the no-LSRD and LSRD groups (p < 0.05 to 0.001). After adjustment, the logistic regression analyses revealed that lysine in DM, alanine, proline and tyrosine in dyslipidemia, histidine, lysine and ornithine in hypertension, and lysine and tyrosine in MetS demonstrated significant positive associations with HU among the patients with LSRDs only (p < 0.05 to 0.005). By contrast, arginine, asparagine and threonine showed significant inverse associations with HU in the no-LSRD group only (p < 0.05 to 0.01). For the first time, we provide evidence for distinct patterns of association between PFAAs and HU in LSRDs, and postulate the possibility of interplay between PFAAs and UA in their pathophysiology. |
format | Online Article Text |
id | pubmed-5732272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57322722017-12-21 Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome Mahbub, MH Yamaguchi, Natsu Takahashi, Hidekazu Hase, Ryosuke Ishimaru, Yasutaka Sunagawa, Hiroshi Amano, Hiroki Kobayashi-Miura, Mikiko Kanda, Hideyuki Fujita, Yasuyuki Yamamoto, Hiroshi Yamamoto, Mai Kikuchi, Shinya Ikeda, Atsuko Kageyama, Naoko Nakamura, Mina Tanabe, Tsuyoshi Sci Rep Article Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects without LSRDs (no-LSRD, n = 2805), and with diabetes mellitus (DM, n = 415), dyslipidemia (n = 3207), hypertension (n = 2736) and metabolic syndrome (MetS, n = 717). The concentrations of most amino acids differed significantly between the subjects with and without hyperuricemia (HU) and also between the no-LSRD and LSRD groups (p < 0.05 to 0.001). After adjustment, the logistic regression analyses revealed that lysine in DM, alanine, proline and tyrosine in dyslipidemia, histidine, lysine and ornithine in hypertension, and lysine and tyrosine in MetS demonstrated significant positive associations with HU among the patients with LSRDs only (p < 0.05 to 0.005). By contrast, arginine, asparagine and threonine showed significant inverse associations with HU in the no-LSRD group only (p < 0.05 to 0.01). For the first time, we provide evidence for distinct patterns of association between PFAAs and HU in LSRDs, and postulate the possibility of interplay between PFAAs and UA in their pathophysiology. Nature Publishing Group UK 2017-12-15 /pmc/articles/PMC5732272/ /pubmed/29247200 http://dx.doi.org/10.1038/s41598-017-17710-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mahbub, MH Yamaguchi, Natsu Takahashi, Hidekazu Hase, Ryosuke Ishimaru, Yasutaka Sunagawa, Hiroshi Amano, Hiroki Kobayashi-Miura, Mikiko Kanda, Hideyuki Fujita, Yasuyuki Yamamoto, Hiroshi Yamamoto, Mai Kikuchi, Shinya Ikeda, Atsuko Kageyama, Naoko Nakamura, Mina Tanabe, Tsuyoshi Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title | Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title_full | Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title_fullStr | Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title_full_unstemmed | Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title_short | Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
title_sort | association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732272/ https://www.ncbi.nlm.nih.gov/pubmed/29247200 http://dx.doi.org/10.1038/s41598-017-17710-6 |
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