Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma

We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a BMI1(High);CHD7(Low) expression signature within medulloblastoma characterizes patients with poor overall survival. We show that BMI1-mediated re...

Descripción completa

Detalles Bibliográficos
Autores principales: Badodi, Sara, Dubuc, Adrian, Zhang, Xinyu, Rosser, Gabriel, Da Cunha Jaeger, Mariane, Kameda-Smith, Michelle M., Morrissy, Anca Sorana, Guilhamon, Paul, Suetterlin, Philipp, Li, Xiao-Nan, Guglielmi, Loredana, Merve, Ashirwad, Farooq, Hamza, Lupien, Mathieu, Singh, Sheila K., Basson, M. Albert, Taylor, Michael D., Marino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732319/
https://www.ncbi.nlm.nih.gov/pubmed/29212025
http://dx.doi.org/10.1016/j.celrep.2017.11.021

Ejemplares similares

Ejemplares similares