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Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice
Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendati...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732517/ https://www.ncbi.nlm.nih.gov/pubmed/29270237 http://dx.doi.org/10.1186/s12263-017-0584-0 |
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author | Grimaldi, Keith A. van Ommen, Ben Ordovas, Jose M. Parnell, Laurence D. Mathers, John C. Bendik, Igor Brennan, Lorraine Celis-Morales, Carlos Cirillo, Elisa Daniel, Hannelore de Kok, Brenda El-Sohemy, Ahmed Fairweather-Tait, Susan J. Fallaize, Rosalind Fenech, Michael Ferguson, Lynnette R. Gibney, Eileen R. Gibney, Mike Gjelstad, Ingrid M. F. Kaput, Jim Karlsen, Anette S. Kolossa, Silvia Lovegrove, Julie Macready, Anna L. Marsaux, Cyril F. M. Alfredo Martinez, J. Milagro, Fermin Navas-Carretero, Santiago Roche, Helen M. Saris, Wim H. M. Traczyk, Iwona van Kranen, Henk Verschuren, Lars Virgili, Fabio Weber, Peter Bouwman, Jildau |
author_facet | Grimaldi, Keith A. van Ommen, Ben Ordovas, Jose M. Parnell, Laurence D. Mathers, John C. Bendik, Igor Brennan, Lorraine Celis-Morales, Carlos Cirillo, Elisa Daniel, Hannelore de Kok, Brenda El-Sohemy, Ahmed Fairweather-Tait, Susan J. Fallaize, Rosalind Fenech, Michael Ferguson, Lynnette R. Gibney, Eileen R. Gibney, Mike Gjelstad, Ingrid M. F. Kaput, Jim Karlsen, Anette S. Kolossa, Silvia Lovegrove, Julie Macready, Anna L. Marsaux, Cyril F. M. Alfredo Martinez, J. Milagro, Fermin Navas-Carretero, Santiago Roche, Helen M. Saris, Wim H. M. Traczyk, Iwona van Kranen, Henk Verschuren, Lars Virgili, Fabio Weber, Peter Bouwman, Jildau |
author_sort | Grimaldi, Keith A. |
collection | PubMed |
description | Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more efficacious at the individual or genetic subgroup level relative to generic dietary advice. Nutrigenetics is unregulated, with no defined standards, beyond some commercially adopted codes of practice. Only a few official nutrition-related professional bodies have embraced the subject, and, consequently, there is a lack of educational resources or guidance for implementation of the outcomes of nutrigenetic research. To avoid misuse and to protect the public, personalised nutrigenetic advice and information should be based on clear evidence of validity grounded in a careful and defensible interpretation of outcomes from nutrigenetic research studies. Evidence requirements are clearly stated and assessed within the context of state-of-the-art ‘evidence-based nutrition’. We have developed and present here a draft framework that can be used to assess the strength of the evidence for scientific validity of nutrigenetic knowledge and whether ‘actionable’. In addition, we propose that this framework be used as the basis for developing transparent and scientifically sound advice to the public based on nutrigenetic tests. We feel that although this area is still in its infancy, minimal guidelines are required. Though these guidelines are based on semi-quantitative data, they should stimulate debate on their utility. This framework will be revised biennially, as knowledge on the subject increases. |
format | Online Article Text |
id | pubmed-5732517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57325172017-12-21 Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice Grimaldi, Keith A. van Ommen, Ben Ordovas, Jose M. Parnell, Laurence D. Mathers, John C. Bendik, Igor Brennan, Lorraine Celis-Morales, Carlos Cirillo, Elisa Daniel, Hannelore de Kok, Brenda El-Sohemy, Ahmed Fairweather-Tait, Susan J. Fallaize, Rosalind Fenech, Michael Ferguson, Lynnette R. Gibney, Eileen R. Gibney, Mike Gjelstad, Ingrid M. F. Kaput, Jim Karlsen, Anette S. Kolossa, Silvia Lovegrove, Julie Macready, Anna L. Marsaux, Cyril F. M. Alfredo Martinez, J. Milagro, Fermin Navas-Carretero, Santiago Roche, Helen M. Saris, Wim H. M. Traczyk, Iwona van Kranen, Henk Verschuren, Lars Virgili, Fabio Weber, Peter Bouwman, Jildau Genes Nutr Review Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more efficacious at the individual or genetic subgroup level relative to generic dietary advice. Nutrigenetics is unregulated, with no defined standards, beyond some commercially adopted codes of practice. Only a few official nutrition-related professional bodies have embraced the subject, and, consequently, there is a lack of educational resources or guidance for implementation of the outcomes of nutrigenetic research. To avoid misuse and to protect the public, personalised nutrigenetic advice and information should be based on clear evidence of validity grounded in a careful and defensible interpretation of outcomes from nutrigenetic research studies. Evidence requirements are clearly stated and assessed within the context of state-of-the-art ‘evidence-based nutrition’. We have developed and present here a draft framework that can be used to assess the strength of the evidence for scientific validity of nutrigenetic knowledge and whether ‘actionable’. In addition, we propose that this framework be used as the basis for developing transparent and scientifically sound advice to the public based on nutrigenetic tests. We feel that although this area is still in its infancy, minimal guidelines are required. Though these guidelines are based on semi-quantitative data, they should stimulate debate on their utility. This framework will be revised biennially, as knowledge on the subject increases. BioMed Central 2017-12-15 /pmc/articles/PMC5732517/ /pubmed/29270237 http://dx.doi.org/10.1186/s12263-017-0584-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Grimaldi, Keith A. van Ommen, Ben Ordovas, Jose M. Parnell, Laurence D. Mathers, John C. Bendik, Igor Brennan, Lorraine Celis-Morales, Carlos Cirillo, Elisa Daniel, Hannelore de Kok, Brenda El-Sohemy, Ahmed Fairweather-Tait, Susan J. Fallaize, Rosalind Fenech, Michael Ferguson, Lynnette R. Gibney, Eileen R. Gibney, Mike Gjelstad, Ingrid M. F. Kaput, Jim Karlsen, Anette S. Kolossa, Silvia Lovegrove, Julie Macready, Anna L. Marsaux, Cyril F. M. Alfredo Martinez, J. Milagro, Fermin Navas-Carretero, Santiago Roche, Helen M. Saris, Wim H. M. Traczyk, Iwona van Kranen, Henk Verschuren, Lars Virgili, Fabio Weber, Peter Bouwman, Jildau Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title | Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title_full | Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title_fullStr | Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title_full_unstemmed | Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title_short | Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
title_sort | proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732517/ https://www.ncbi.nlm.nih.gov/pubmed/29270237 http://dx.doi.org/10.1186/s12263-017-0584-0 |
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