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Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells

BACKGROUND: The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulation, which was shown i.e. in pancreatic cancer. Until now, hypoxia has been def...

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Detalles Bibliográficos
Autores principales:	Bielecka, Zofia F., Malinowska, Agata, Brodaczewska, Klaudia K., Klemba, Aleksandra, Kieda, Claudine, Krasowski, Paweł, Grzesiuk, Elżbieta, Piwowarski, Jan, Czarnecka, Anna M., Szczylik, Cezary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732521/ https://www.ncbi.nlm.nih.gov/pubmed/29270287 http://dx.doi.org/10.1186/s13578-017-0197-8

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