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Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α

We investigated the role of HIF-1α in the mitigation of cisplatin-induced nephrotoxicity by Panax notoginseng saponins (PNS) in a rat model. Serum creatinine (Scr), blood urea nitrogen (BUN) and urinary N-acetyl-β-D-glucosaminidase (NAG) levels were all elevated in cisplatin treated rats. PNS reduce...

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Detalles Bibliográficos
Autores principales:	Liang, Xueyan, Yang, Yufang, Huang, Zhenguang, Zhou, Jinling, Li, Yue’e, Zhong, Xiaobin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732705/ https://www.ncbi.nlm.nih.gov/pubmed/29262539 http://dx.doi.org/10.18632/oncotarget.19900

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