GATA3 frameshift mutation promotes tumor growth in human luminal breast cancer cells and induces transcriptional changes seen in primary GATA3 mutant breast cancers

The GATA3 transcription factor is one of the most frequently mutated genes in breast cancer. Heterozygous mutations, mostly frameshifts, are seen in 15% of estrogen receptor positive breast cancers, the subtype in which these mutations are almost exclusively found. Mouse studies have shown that Gata...

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Detalles Bibliográficos
Autores principales: Gustin, John P., Miller, Jernelle, Farag, Mina, Rosen, D. Marc, Thomas, Matthew, Scharpf, Robert B., Lauring, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732738/
https://www.ncbi.nlm.nih.gov/pubmed/29262572
http://dx.doi.org/10.18632/oncotarget.21910

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