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Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors

mTOR pathway activation and hypervascularity have been identified as important characteristics of pancreatic neuroendocrine tumors (pNETs). Agents targeting angiogenesis and mTOR, such as sunitinib and everolimus (RAD001), have been shown to result in progression-free survival of approximately 11 mo...

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Detalles Bibliográficos
Autores principales:	Chu, Pei-Yi, Jiang, Shih Sheng, Shan, Yan-Shen, Hung, Wen-Chun, Chen, Ming-Huang, Lin, Hui-You, Chen, Yu-Lin, Tsai, Hui-Jen, Chen, Li-Tzong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732754/ https://www.ncbi.nlm.nih.gov/pubmed/29262588 http://dx.doi.org/10.18632/oncotarget.21665

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