Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

PURPOSE: To determine the pharmacodynamic effects of Sonidegib (LDE-225) in prostate tumor tissue from men with high-risk localized prostate cancer, by comparing pre-surgical core-biopsy specimens to tumor tissue harvested post-treatment at prostatectomy. METHODS: We conducted a prospective randomiz...

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Detalles Bibliográficos
Autores principales: Ross, Ashley E., Hughes, Robert M., Glavaris, Stephanie, Ghabili, Kamyar, He, Ping, Anders, Nicole M., Harb, Rana, Tosoian, Jeffrey J., Marchionni, Luigi, Schaeffer, Edward M., Partin, Alan W., Allaf, Mohamad E., Bivalacqua, Trinity J., Chapman, Carolyn, O’Neal, Tanya, DeMarzo, Angelo M., Hurley, Paula J., Rudek, Michelle A., Antonarakis, Emmanuel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732797/
https://www.ncbi.nlm.nih.gov/pubmed/29262631
http://dx.doi.org/10.18632/oncotarget.22115

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