Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K(b) Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome

Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated with high fatality rates. Cytotoxic T cell (CTL) responses contribute to virus elimination; however, to date, HLA class I allele-restricted HTNV glycoprotein (GP) epitopes rec...

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Detalles Bibliográficos
Autores principales: Tang, Kang, Cheng, Linfeng, Zhang, Chunmei, Zhang, Yusi, Zheng, Xuyang, Zhang, Yun, Zhuang, Ran, Jin, Boquan, Zhang, Fanglin, Ma, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732971/
https://www.ncbi.nlm.nih.gov/pubmed/29312318
http://dx.doi.org/10.3389/fimmu.2017.01797

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