Cargando…

Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods

The auditory steady-state response (ASSR) is one of the main approaches in clinic for health screening and frequency-specific hearing assessment. However, its generation mechanism is still of much controversy. In the present study, the linear superposition hypothesis for the generation of ASSRs was...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Xiaodan, Fu, Qiuyang, Yuan, Han, Ding, Lei, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732975/
https://www.ncbi.nlm.nih.gov/pubmed/29311778
http://dx.doi.org/10.3389/fnins.2017.00697
_version_ 1783286809652887552
author Tan, Xiaodan
Fu, Qiuyang
Yuan, Han
Ding, Lei
Wang, Tao
author_facet Tan, Xiaodan
Fu, Qiuyang
Yuan, Han
Ding, Lei
Wang, Tao
author_sort Tan, Xiaodan
collection PubMed
description The auditory steady-state response (ASSR) is one of the main approaches in clinic for health screening and frequency-specific hearing assessment. However, its generation mechanism is still of much controversy. In the present study, the linear superposition hypothesis for the generation of ASSRs was investigated by comparing the relationships between the classical 40 Hz ASSR and three synthetic ASSRs obtained from three different templates for transient auditory evoked potential (AEP). These three AEPs are the traditional AEP at 5 Hz and two 40 Hz AEPs derived from two deconvolution algorithms using stimulus sequences, i.e., continuous loop averaging deconvolution (CLAD) and multi-rate steady-state average deconvolution (MSAD). CLAD requires irregular inter-stimulus intervals (ISIs) in the sequence while MSAD uses the same ISIs but evenly-spaced stimulus sequences which mimics the classical 40 Hz ASSR. It has been reported that these reconstructed templates show similar patterns but significant difference in morphology and distinct frequency characteristics in synthetic ASSRs. The prediction accuracies of ASSR using these templates show significant differences (p < 0.05) in 45.95, 36.28, and 10.84% of total time points within four cycles of ASSR for the traditional, CLAD, and MSAD templates, respectively, as compared with the classical 40 Hz ASSR, and the ASSR synthesized from the MSAD transient AEP suggests the best similarity. And such a similarity is also demonstrated at individuals only in MSAD showing no statistically significant difference (Hotelling's T(2) test, T(2) = 6.96, F = 0.80, p = 0.592) as compared with the classical 40 Hz ASSR. The present results indicate that both stimulation rate and sequencing factor (ISI variation) affect transient AEP reconstructions from steady-state stimulation protocols. Furthermore, both auditory brainstem response (ABR) and middle latency response (MLR) are observed in contributing to the composition of ASSR but with variable weights in three templates. The significantly improved prediction accuracy of ASSR achieved by MSAD strongly supports the linear superposition mechanism of ASSR if an accurate template of transient AEPs can be reconstructed. The capacity in obtaining both ASSR and its underlying transient components accurately and simultaneously has the potential to contribute significantly to diagnosis of patients with neuropsychiatric disorders.
format Online
Article
Text
id pubmed-5732975
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-57329752018-01-08 Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods Tan, Xiaodan Fu, Qiuyang Yuan, Han Ding, Lei Wang, Tao Front Neurosci Neuroscience The auditory steady-state response (ASSR) is one of the main approaches in clinic for health screening and frequency-specific hearing assessment. However, its generation mechanism is still of much controversy. In the present study, the linear superposition hypothesis for the generation of ASSRs was investigated by comparing the relationships between the classical 40 Hz ASSR and three synthetic ASSRs obtained from three different templates for transient auditory evoked potential (AEP). These three AEPs are the traditional AEP at 5 Hz and two 40 Hz AEPs derived from two deconvolution algorithms using stimulus sequences, i.e., continuous loop averaging deconvolution (CLAD) and multi-rate steady-state average deconvolution (MSAD). CLAD requires irregular inter-stimulus intervals (ISIs) in the sequence while MSAD uses the same ISIs but evenly-spaced stimulus sequences which mimics the classical 40 Hz ASSR. It has been reported that these reconstructed templates show similar patterns but significant difference in morphology and distinct frequency characteristics in synthetic ASSRs. The prediction accuracies of ASSR using these templates show significant differences (p < 0.05) in 45.95, 36.28, and 10.84% of total time points within four cycles of ASSR for the traditional, CLAD, and MSAD templates, respectively, as compared with the classical 40 Hz ASSR, and the ASSR synthesized from the MSAD transient AEP suggests the best similarity. And such a similarity is also demonstrated at individuals only in MSAD showing no statistically significant difference (Hotelling's T(2) test, T(2) = 6.96, F = 0.80, p = 0.592) as compared with the classical 40 Hz ASSR. The present results indicate that both stimulation rate and sequencing factor (ISI variation) affect transient AEP reconstructions from steady-state stimulation protocols. Furthermore, both auditory brainstem response (ABR) and middle latency response (MLR) are observed in contributing to the composition of ASSR but with variable weights in three templates. The significantly improved prediction accuracy of ASSR achieved by MSAD strongly supports the linear superposition mechanism of ASSR if an accurate template of transient AEPs can be reconstructed. The capacity in obtaining both ASSR and its underlying transient components accurately and simultaneously has the potential to contribute significantly to diagnosis of patients with neuropsychiatric disorders. Frontiers Media S.A. 2017-12-12 /pmc/articles/PMC5732975/ /pubmed/29311778 http://dx.doi.org/10.3389/fnins.2017.00697 Text en Copyright © 2017 Tan, Fu, Yuan, Ding and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tan, Xiaodan
Fu, Qiuyang
Yuan, Han
Ding, Lei
Wang, Tao
Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title_full Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title_fullStr Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title_full_unstemmed Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title_short Improved Transient Response Estimations in Predicting 40 Hz Auditory Steady-State Response Using Deconvolution Methods
title_sort improved transient response estimations in predicting 40 hz auditory steady-state response using deconvolution methods
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732975/
https://www.ncbi.nlm.nih.gov/pubmed/29311778
http://dx.doi.org/10.3389/fnins.2017.00697
work_keys_str_mv AT tanxiaodan improvedtransientresponseestimationsinpredicting40hzauditorysteadystateresponseusingdeconvolutionmethods
AT fuqiuyang improvedtransientresponseestimationsinpredicting40hzauditorysteadystateresponseusingdeconvolutionmethods
AT yuanhan improvedtransientresponseestimationsinpredicting40hzauditorysteadystateresponseusingdeconvolutionmethods
AT dinglei improvedtransientresponseestimationsinpredicting40hzauditorysteadystateresponseusingdeconvolutionmethods
AT wangtao improvedtransientresponseestimationsinpredicting40hzauditorysteadystateresponseusingdeconvolutionmethods