Cargando…

Alteration in Intracellular Zn(2+) Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

Transient receptor potential melastatin-related 2 (TRPM2) channel, a molecular sensor for reactive oxygen species (ROS), plays an important role in cognitive dysfunction associated with post-ischemia brain damage thought to result from ROS-induced TRPM2-dependent neuronal death during reperfusion. E...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xin, Yang, Wei, Jiang, Lin-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732979/ https://www.ncbi.nlm.nih.gov/pubmed/29311807 http://dx.doi.org/10.3389/fnmol.2017.00414

Ejemplares similares

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
por: Belrose, Jillian C, et al.
Publicado: (2012)

Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells
por: Mortadza, Sharifah Syed, et al.
Publicado: (2017)

TRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune Cells
por: Syed Mortadza, Sharifah Alawieyah, et al.
Publicado: (2015)

Remodeling of Intracellular Ca(2+) Homeostasis in Rat Hippocampal Neurons Aged In Vitro
por: Calvo-Rodriguez, Maria, et al.
Publicado: (2020)

TRPM2 channel deficiency prevents delayed cytosolic Zn(2+) accumulation and CA1 pyramidal neuronal death after transient global ischemia
por: Ye, M, et al.
Publicado: (2014)

The ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis
por: Perraud, Anne-Laure, et al.
Publicado: (2018)

Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy
por: Hu, Xupang, et al.
Publicado: (2021)

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
por: Di, Anke, et al.
Publicado: (2011)

Targeting TRPM2 in ROS-Coupled Diseases
por: Yamamoto, Shinichiro, et al.
Publicado: (2016)

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
por: An, Xinfang, et al.
Publicado: (2019)

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons
por: Lei, Ya-Ting, et al.
Publicado: (2014)

Intracellular Zn(2+) transients modulate global gene expression in dissociated rat hippocampal neurons
por: Sanford, Lynn, et al.
Publicado: (2019)

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture
por: Stritt, Simon, et al.
Publicado: (2016)

Structural mechanism of TRPM7 channel regulation by intracellular magnesium
por: Schmidt, Eva, et al.
Publicado: (2022)

Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway
por: Sha’fie, Muhammad Syahreel Azhad, et al.
Publicado: (2020)

Regulation of TRPM2 by Extra- and Intracellular Calcium
por: Starkus, John, et al.
Publicado: (2007)

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP
por: Ferioli, Silvia, et al.
Publicado: (2017)

Contribution of NAADP to Glutamate-Evoked Changes in Ca(2+) Homeostasis in Mouse Hippocampal Neurons
por: Hermann, Julia, et al.
Publicado: (2020)

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
por: Akyuva, Yener, et al.
Publicado: (2020)

The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis
por: Nadolni, Wiebke, et al.
Publicado: (2018)

TRPM7 is essential for Mg(2+) homeostasis in mammals
por: Ryazanova, Lillia V., et al.
Publicado: (2010)

Inactivation of TRPM2 Channels by Extracellular Divalent Copper
por: Yu, Wenyue, et al.
Publicado: (2014)

Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons
por: Li, Xin, et al.
Publicado: (2018)

Four Ca(2+) Ions Activate TRPM2 Channels by Binding in Deep Crevices near the Pore but Intracellularly of the Gate
por: Csanády, László, et al.
Publicado: (2009)

Alterations in ZnT1 expression and function lead to impaired intracellular zinc homeostasis in cancer
por: Lehvy, Adrian Israel, et al.
Publicado: (2019)

TRPM2 channels in mitochondrial dynamics and cancer
por: Sivaprasadarao, Asipu, et al.
Publicado: (2017)

The TRPM2 channel in temperature detection and thermoregulation
por: Kamm, Gretel B., et al.
Publicado: (2016)

Volume Regulated Anion Channel Currents of Rat Hippocampal Neurons and Their Contribution to Oxygen-and-Glucose Deprivation Induced Neuronal Death
por: Zhang, Huaqiu, et al.
Publicado: (2011)

TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase
por: Ferrera, Loretta, et al.
Publicado: (2021)

Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 3: the roles and properties of TRPM2 and TRPM7
por: Okada, Yasunobu, et al.
Publicado: (2023)

Ginkgolide B Maintains Calcium Homeostasis in Hypoxic Hippocampal Neurons by Inhibiting Calcium Influx and Intracellular Calcium Release
por: Wang, Li, et al.
Publicado: (2021)

The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice
por: Belaïdouni, Yasmine, et al.
Publicado: (2021)

TRPM2 Cation Channels Modulate T Cell Effector Functions and Contribute to Autoimmune CNS Inflammation
por: Melzer, Nico, et al.
Publicado: (2012)

TRPM2: bridging calcium and ROS signaling pathways—implications for human diseases
por: Maliougina, Maria, et al.
Publicado: (2023)

The TRPM2 ion channel is required for sensitivity to warmth
por: Tan, Chun-Hsiang, et al.
Publicado: (2016)

Comparative Effects of Heterologous TRPV1 and TRPM8 Expression in Rat Hippocampal Neurons
por: Crawford, Devon C., et al.
Publicado: (2009)

State-dependent Inhibition of TRPM2 Channel by Acidic pH
por: Yang, Wei, et al.
Publicado: (2010)

TRPM Family Channels in Cancer
por: Hantute-Ghesquier, Aline, et al.
Publicado: (2018)

TRPM Channels in Human Diseases
por: Jimenez, Ivanka, et al.
Publicado: (2020)

The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia
por: Turlova, Ekaterina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uesl5h8d2lconnqjrssp4co5ab