Effects of Apelin on Cardiovascular Aging

Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin–APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with...

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Detalles Bibliográficos
Autores principales: Zhou, Ying, Wang, Yong, Qiao, Shubin, Yin, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732982/
https://www.ncbi.nlm.nih.gov/pubmed/29302260
http://dx.doi.org/10.3389/fphys.2017.01035
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author Zhou, Ying
Wang, Yong
Qiao, Shubin
Yin, Liang
author_facet Zhou, Ying
Wang, Yong
Qiao, Shubin
Yin, Liang
author_sort Zhou, Ying
collection PubMed
description Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin–APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in the elderly, such as atherosclerosis, coronary atherosclerotic heart disease, hypertension, calcific aortic valve disease, heart failure and atrial fibrillation. In this review, we discuss the apelin–APJ signal transduction pathway related to age-associated cardiovascular diseases.
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spelling pubmed-57329822018-01-04 Effects of Apelin on Cardiovascular Aging Zhou, Ying Wang, Yong Qiao, Shubin Yin, Liang Front Physiol Physiology Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin–APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in the elderly, such as atherosclerosis, coronary atherosclerotic heart disease, hypertension, calcific aortic valve disease, heart failure and atrial fibrillation. In this review, we discuss the apelin–APJ signal transduction pathway related to age-associated cardiovascular diseases. Frontiers Media S.A. 2017-12-12 /pmc/articles/PMC5732982/ /pubmed/29302260 http://dx.doi.org/10.3389/fphys.2017.01035 Text en Copyright © 2017 Zhou, Wang, Qiao and Yin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhou, Ying
Wang, Yong
Qiao, Shubin
Yin, Liang
Effects of Apelin on Cardiovascular Aging
title Effects of Apelin on Cardiovascular Aging
title_full Effects of Apelin on Cardiovascular Aging
title_fullStr Effects of Apelin on Cardiovascular Aging
title_full_unstemmed Effects of Apelin on Cardiovascular Aging
title_short Effects of Apelin on Cardiovascular Aging
title_sort effects of apelin on cardiovascular aging
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732982/
https://www.ncbi.nlm.nih.gov/pubmed/29302260
http://dx.doi.org/10.3389/fphys.2017.01035
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AT yinliang effectsofapelinoncardiovascularaging

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