The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

Possession of the ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the precise cause of this increased AD risk is not yet known. In order to gain a more comprehensive understanding of...

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Detalles Bibliográficos
Autores principales: Nuriel, Tal, Peng, Katherine Y., Ashok, Archana, Dillman, Allissa A., Figueroa, Helen Y., Apuzzo, Justin, Ambat, Jayanth, Levy, Efrat, Cookson, Mark R., Mathews, Paul M., Duff, Karen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733017/
https://www.ncbi.nlm.nih.gov/pubmed/29311783
http://dx.doi.org/10.3389/fnins.2017.00702

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