Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP

Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduces ChAT enzyme activity and cellular protein levels...

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Detalles Bibliográficos
Autores principales: Morey, Trevor M., Winick-Ng, Warren, Seah, Claudia, Rylett, R. Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733026/
https://www.ncbi.nlm.nih.gov/pubmed/29311808
http://dx.doi.org/10.3389/fnmol.2017.00415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733026/
https://www.ncbi.nlm.nih.gov/pubmed/29311808
http://dx.doi.org/10.3389/fnmol.2017.00415

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