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Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous woun...

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Autores principales: Jiang, Xiao-wen, Qiao, Lu, Liu, Lin, Zhang, Bin-qing, Wang, Xue-wei, Han, Yu-wen, Yu, Wen-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733224/
https://www.ncbi.nlm.nih.gov/pubmed/29333188
http://dx.doi.org/10.1155/2017/8950516
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author Jiang, Xiao-wen
Qiao, Lu
Liu, Lin
Zhang, Bin-qing
Wang, Xue-wei
Han, Yu-wen
Yu, Wen-hui
author_facet Jiang, Xiao-wen
Qiao, Lu
Liu, Lin
Zhang, Bin-qing
Wang, Xue-wei
Han, Yu-wen
Yu, Wen-hui
author_sort Jiang, Xiao-wen
collection PubMed
description Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.
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spelling pubmed-57332242018-01-14 Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats Jiang, Xiao-wen Qiao, Lu Liu, Lin Zhang, Bin-qing Wang, Xue-wei Han, Yu-wen Yu, Wen-hui Evid Based Complement Alternat Med Research Article Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing. Hindawi 2017 2017-12-03 /pmc/articles/PMC5733224/ /pubmed/29333188 http://dx.doi.org/10.1155/2017/8950516 Text en Copyright © 2017 Xiao-wen Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Xiao-wen
Qiao, Lu
Liu, Lin
Zhang, Bin-qing
Wang, Xue-wei
Han, Yu-wen
Yu, Wen-hui
Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title_full Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title_fullStr Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title_full_unstemmed Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title_short Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
title_sort dracorhodin perchlorate accelerates cutaneous wound healing in wistar rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733224/
https://www.ncbi.nlm.nih.gov/pubmed/29333188
http://dx.doi.org/10.1155/2017/8950516
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