Cargando…

SOX6 Downregulation Induces γ-Globin in Human β-Thalassemia Major Erythroid Cells

BACKGROUND: Fetal hemoglobin (HbF; α(2)γ(2)) is a potent genetic modifier of the severity of β-thalassemia and sickle cell anemia. Differences in the levels of HbF that persist into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Sry type HMG box (SOX6) is a pot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jing, Lai, Yongrong, Luo, Jun, Luo, Lin, Liu, Rongrong, Liu, Zhenfang, Zhao, Weihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733236/ https://www.ncbi.nlm.nih.gov/pubmed/29333458 http://dx.doi.org/10.1155/2017/9496058

Ejemplares similares

Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major
por: Sun, Kuo-Ting, et al.
Publicado: (2017)

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation
por: Ruiz, Maria Armila, et al.
Publicado: (2015)

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
por: Cantu', Claudio, et al.
Publicado: (2011)

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production
por: Breveglieri, Giulia, et al.
Publicado: (2017)

Eos Negatively Regulates Human γ-globin Gene Transcription during Erythroid Differentiation
por: Yu, Hai-Chuan, et al.
Publicado: (2011)

Identification of novel γ-globin inducers among all potential erythroid druggable targets
por: Yu, Lei, et al.
Publicado: (2022)

Efficient CRISPR-Cas9-based genome editing of β-globin gene on erythroid cells from homozygous β(0)39-thalassemia patients
por: Cosenza, Lucia Carmela, et al.
Publicado: (2021)

β-Thalassemia Intermedia: Interaction of α-Globin Gene Triplication With β-thalassemia Heterozygous in Spain
por: Ropero, Paloma, et al.
Publicado: (2022)

Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major
por: Psatha, Nikoletta, et al.
Publicado: (2018)

DNA methylation patterns of β-globin cluster in β-thalassemia patients
por: Bao, Xiuqin, et al.
Publicado: (2020)

Beta Globin Frameworks in Thalassemia Major Patients from North Iran
por: Akhavan-Niaki, Haleh, et al.
Publicado: (2012)

Proteomic Studies for the Investigation of γ-Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures
por: Theodorou, Andria, et al.
Publicado: (2020)

An early start of Coup-TFII promotes γ-globin gene expression in adult erythroid cells
por: Bottardi, Stefania, et al.
Publicado: (2021)

β-Globin chain abnormalities with coexisting α-thalassemia mutations
por: Guvenc, Birol, et al.
Publicado: (2012)

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus
por: Zurlo, Matteo, et al.
Publicado: (2023)

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β(0)39-Globin Gene Editing and Induction of Fetal Hemoglobin
por: Cosenza, Lucia Carmela, et al.
Publicado: (2022)

Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia
por: Nualkaew, Tiwaporn, et al.
Publicado: (2021)

Spectrum of Beta Globin Gene Mutations in Egyptian Children with β-Thalassemia
por: El-Shanshory, MR, et al.
Publicado: (2014)

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
por: Zuccato, Cristina, et al.
Publicado: (2023)

Sox6 Directly Silences Epsilon Globin Expression in Definitive Erythropoiesis
por: Yi, Zanhua, et al.
Publicado: (2006)

P104: BASE EDITING REPAIRS THE HBE MUTATION RESTORING THE PRODUCTION OF NORMAL GLOBIN CHAINS IN SEVERE HBE/β-THALASSEMIA PATIENT HEMATOPOIETIC STEM AND ERYTHROID CELLS
por: Badat, M, et al.
Publicado: (2022)

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin)
por: Zuccato, Cristina, et al.
Publicado: (2022)

CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia
por: Yang, Yi, et al.
Publicado: (2021)

How Early Can Myocardial Iron Overload Occur in Beta Thalassemia Major?
por: Yang, Gaohui, et al.
Publicado: (2014)

The methyltransferase PRMT1 regulates γ-globin translation
por: Wang, Ying, et al.
Publicado: (2021)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
por: Funnell, Alister PW, et al.
Publicado: (2014)

Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression
por: Lee, Tze Yan, et al.
Publicado: (2016)

Imbalance of erythropoiesis and iron metabolism in patients with thalassemia
por: Huang, Yumei, et al.
Publicado: (2019)

Investigating the Efficacy and Safety of Thalidomide for Treating Patients With ß-Thalassemia: A Meta-Analysis
por: Lu, Yanfei, et al.
Publicado: (2022)

Analysis of (G)γ-158(C→T) polymorphism in hemoglobin E/β-thalassemia major in Southern China
por: Liu, Rong Rong, et al.
Publicado: (2010)

A novel mutation in the erythroid transcription factor KLF1 is likely responsible for ameliorating β‐thalassemia major
por: Fanis, Pavlos, et al.
Publicado: (2019)

PB2238: ΒETA-THALASSEMIA INTERMEDIA: INTERACTION OF ΑLPHA-GLOBIN GENE TRIPLICATION WITH ΒETA-THALASSEMIA HETEROZYGOUS IN SPAIN
por: Ropero, P., et al.
Publicado: (2022)

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation for thalassemia major: incidence, management, and outcome
por: Lai, Xiaoxuan, et al.
Publicado: (2021)

Distribution of β-Globin Gene Mutations in Thalassemia Minor Population of Kerman Province, Iran
por: Saleh-Gohari, N, et al.
Publicado: (2010)

Erythroid-Specific Expression of β-globin from Sleeping Beauty-Transduced Human Hematopoietic Progenitor Cells
por: Sjeklocha, Lucas M., et al.
Publicado: (2011)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
por: Lu, Dian, et al.
Publicado: (2022)

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011)

EF Bart's Disease with Coinheritance of Gγ-XmnI and Aγ-Globin Polymorphisms: A Case of Nontransfusion-Dependant Thalassemia
por: Laks, Kane M., et al.
Publicado: (2020)

Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
por: Huang, Yumei, et al.
Publicado: (2019)

Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia
por: Piga, Antonio, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pqprk2gqvt5bghr94qe76sqtlm