Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

[Image: see text] A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro and in cells, and is able to induce a...

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Detalles Bibliográficos
Autores principales: Pasini, Alice, Marchetti, Chiara, Sissi, Claudia, Cortesi, Marilisa, Giordano, Emanuele, Minarini, Anna, Milelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733267/
https://www.ncbi.nlm.nih.gov/pubmed/29259737
http://dx.doi.org/10.1021/acsmedchemlett.7b00289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733267/
https://www.ncbi.nlm.nih.gov/pubmed/29259737
http://dx.doi.org/10.1021/acsmedchemlett.7b00289

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