Cargando…

A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India

BACKGROUND: Opioid substitution therapy (OST) is an evidence-based intervention for opiate-dependent persons that replaces illicit drug use with medically prescribed, orally administered opiates such as buprenorphine and methadone. OST reduces HIV risk behaviors and harms associated with injecting o...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohapatra, Satyakam, Nayak, Mihir Ranjan, Dash, Manaswini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733424/
https://www.ncbi.nlm.nih.gov/pubmed/29284807
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_61_17
_version_ 1783286896610246656
author Mohapatra, Satyakam
Nayak, Mihir Ranjan
Dash, Manaswini
author_facet Mohapatra, Satyakam
Nayak, Mihir Ranjan
Dash, Manaswini
author_sort Mohapatra, Satyakam
collection PubMed
description BACKGROUND: Opioid substitution therapy (OST) is an evidence-based intervention for opiate-dependent persons that replaces illicit drug use with medically prescribed, orally administered opiates such as buprenorphine and methadone. OST reduces HIV risk behaviors and harms associated with injecting opioid. Most of the evidence for OST effectiveness has been generated in middle- and high-income countries where programs are mostly located in dedicated health-care settings; evidence regarding the outcomes of OST programs in low-income countries where OST is often provided in grassroots settings such as drop-in centers is limited. AIMS AND OBJECTIVES: To study the sociodemographic variables, HIV ELISA status, HIV risk behavior, comorbid substance use pattern, and required dose of buprenorphine used for treatment of injection drug users (IDUs) attending oral substitution therapy (OST) center at a tertiary health care center. METHODOLOGY: A total of IDUs aged 18–60 years who attended the OST center during 1-year period at a government medical college are included in the study. RESULTS: Majority of the IDUs are male with mean age of 32.8 years. The mean dose of buprenorphine used for the substitution was 4.6 mg/day at the start of therapy. Most of the IDUs are of lower educational status and educated up to primary or middle school. 32.50% of the participants who are unemployed are totally dependent on the family. Most common substance abuse among IDU users were tobacco (74.17%), followed by heroine (57.5%). High-risk behavior found among OST clients was unprotected sexual intercourse (19.17%), sharing needle (11.67%), and sexual intercourse with multiple partners (6.67%). HIV ELISA testing showed positive among 2 (1.67%). CONCLUSION: These findings have relevance to other parts of India and Asia, where injecting drug use is common and is a first step toward filling the gap in knowledge regarding the effectiveness of community-based OST programs delivered in resource-constrained settings.
format Online
Article
Text
id pubmed-5733424
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-57334242017-12-28 A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India Mohapatra, Satyakam Nayak, Mihir Ranjan Dash, Manaswini Indian J Psychol Med Original Article BACKGROUND: Opioid substitution therapy (OST) is an evidence-based intervention for opiate-dependent persons that replaces illicit drug use with medically prescribed, orally administered opiates such as buprenorphine and methadone. OST reduces HIV risk behaviors and harms associated with injecting opioid. Most of the evidence for OST effectiveness has been generated in middle- and high-income countries where programs are mostly located in dedicated health-care settings; evidence regarding the outcomes of OST programs in low-income countries where OST is often provided in grassroots settings such as drop-in centers is limited. AIMS AND OBJECTIVES: To study the sociodemographic variables, HIV ELISA status, HIV risk behavior, comorbid substance use pattern, and required dose of buprenorphine used for treatment of injection drug users (IDUs) attending oral substitution therapy (OST) center at a tertiary health care center. METHODOLOGY: A total of IDUs aged 18–60 years who attended the OST center during 1-year period at a government medical college are included in the study. RESULTS: Majority of the IDUs are male with mean age of 32.8 years. The mean dose of buprenorphine used for the substitution was 4.6 mg/day at the start of therapy. Most of the IDUs are of lower educational status and educated up to primary or middle school. 32.50% of the participants who are unemployed are totally dependent on the family. Most common substance abuse among IDU users were tobacco (74.17%), followed by heroine (57.5%). High-risk behavior found among OST clients was unprotected sexual intercourse (19.17%), sharing needle (11.67%), and sexual intercourse with multiple partners (6.67%). HIV ELISA testing showed positive among 2 (1.67%). CONCLUSION: These findings have relevance to other parts of India and Asia, where injecting drug use is common and is a first step toward filling the gap in knowledge regarding the effectiveness of community-based OST programs delivered in resource-constrained settings. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5733424/ /pubmed/29284807 http://dx.doi.org/10.4103/IJPSYM.IJPSYM_61_17 Text en Copyright: © 2017 Indian Psychiatric Society http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mohapatra, Satyakam
Nayak, Mihir Ranjan
Dash, Manaswini
A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title_full A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title_fullStr A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title_full_unstemmed A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title_short A Clinical Study of Opioid Substitution Therapy in a Tertiary Care Center of Eastern India
title_sort clinical study of opioid substitution therapy in a tertiary care center of eastern india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733424/
https://www.ncbi.nlm.nih.gov/pubmed/29284807
http://dx.doi.org/10.4103/IJPSYM.IJPSYM_61_17
work_keys_str_mv AT mohapatrasatyakam aclinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia
AT nayakmihirranjan aclinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia
AT dashmanaswini aclinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia
AT mohapatrasatyakam clinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia
AT nayakmihirranjan clinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia
AT dashmanaswini clinicalstudyofopioidsubstitutiontherapyinatertiarycarecenterofeasternindia