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Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage

The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to t...

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Autores principales: Newsome, Rachel N., Trelle, Alexandra N., Fidalgo, Celia, Hong, Bryan, Smith, Victoria M., Jacob, Alexander, Ryan, Jennifer D., Rosenbaum, R. Shayna, Cowell, Rosemary A., Barense, Morgan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733467/
https://www.ncbi.nlm.nih.gov/pubmed/29246979
http://dx.doi.org/10.1101/lm.045484.117
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author Newsome, Rachel N.
Trelle, Alexandra N.
Fidalgo, Celia
Hong, Bryan
Smith, Victoria M.
Jacob, Alexander
Ryan, Jennifer D.
Rosenbaum, R. Shayna
Cowell, Rosemary A.
Barense, Morgan D.
author_facet Newsome, Rachel N.
Trelle, Alexandra N.
Fidalgo, Celia
Hong, Bryan
Smith, Victoria M.
Jacob, Alexander
Ryan, Jennifer D.
Rosenbaum, R. Shayna
Cowell, Rosemary A.
Barense, Morgan D.
author_sort Newsome, Rachel N.
collection PubMed
description The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to the anterior thalamic nuclei leads to impairments in hippocampal-dependent tasks. However, evidence for the opposite pattern following medial dorsal nuclei damage has not yet been identified. In the present study, we investigated recognition memory in NC, a patient with relatively selective medial dorsal nuclei damage, using two object recognition tests with similar foils: a yes/no (YN) test that requires the hippocampus, and a forced choice corresponding test (FCC) that is supported by perirhinal cortex. NC performed normally in the YN test, but was impaired in the FCC test. Critically, FCC performance was impaired only when the study-test delay period was filled with interference. We interpret these results in the context of the representational–hierarchical model, which predicts that memory deficits following damage to the perirhinal system arise due to increased vulnerability to interference. These data provide the first evidence for selective deficits in a task that relies on perirhinal output following damage to the medial dorsal nuclei, providing critical evidence for dissociable thalamic contributions to recognition memory.
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spelling pubmed-57334672019-01-01 Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage Newsome, Rachel N. Trelle, Alexandra N. Fidalgo, Celia Hong, Bryan Smith, Victoria M. Jacob, Alexander Ryan, Jennifer D. Rosenbaum, R. Shayna Cowell, Rosemary A. Barense, Morgan D. Learn Mem Research The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to the anterior thalamic nuclei leads to impairments in hippocampal-dependent tasks. However, evidence for the opposite pattern following medial dorsal nuclei damage has not yet been identified. In the present study, we investigated recognition memory in NC, a patient with relatively selective medial dorsal nuclei damage, using two object recognition tests with similar foils: a yes/no (YN) test that requires the hippocampus, and a forced choice corresponding test (FCC) that is supported by perirhinal cortex. NC performed normally in the YN test, but was impaired in the FCC test. Critically, FCC performance was impaired only when the study-test delay period was filled with interference. We interpret these results in the context of the representational–hierarchical model, which predicts that memory deficits following damage to the perirhinal system arise due to increased vulnerability to interference. These data provide the first evidence for selective deficits in a task that relies on perirhinal output following damage to the medial dorsal nuclei, providing critical evidence for dissociable thalamic contributions to recognition memory. Cold Spring Harbor Laboratory Press 2018-01 /pmc/articles/PMC5733467/ /pubmed/29246979 http://dx.doi.org/10.1101/lm.045484.117 Text en © 2018 Newsome et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Newsome, Rachel N.
Trelle, Alexandra N.
Fidalgo, Celia
Hong, Bryan
Smith, Victoria M.
Jacob, Alexander
Ryan, Jennifer D.
Rosenbaum, R. Shayna
Cowell, Rosemary A.
Barense, Morgan D.
Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title_full Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title_fullStr Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title_full_unstemmed Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title_short Dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
title_sort dissociable contributions of thalamic nuclei to recognition memory: novel evidence from a case of medial dorsal thalamic damage
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733467/
https://www.ncbi.nlm.nih.gov/pubmed/29246979
http://dx.doi.org/10.1101/lm.045484.117
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