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Stress leads to aberrant hippocampal involvement when processing schema-related information
Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733469/ https://www.ncbi.nlm.nih.gov/pubmed/29246978 http://dx.doi.org/10.1101/lm.046003.117 |
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author | Vogel, Susanne Kluen, Lisa Marieke Fernández, Guillén Schwabe, Lars |
author_facet | Vogel, Susanne Kluen, Lisa Marieke Fernández, Guillén Schwabe, Lars |
author_sort | Vogel, Susanne |
collection | PubMed |
description | Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting schema activated by a specific cue. Participants’ memory for the presented material was tested 3–5 d after encoding. Overall, the processing of schema-related information activated the mPFC, the precuneus, and the angular gyrus. Stress resulted in aberrant hippocampal activity and connectivity while participants processed schema-related information. This aberrant engagement of the hippocampus was linked to altered subsequent memory. These findings suggest that stress may interfere with the efficient use of prior knowledge during encoding and may have important practical implications, in particular for educational settings. |
format | Online Article Text |
id | pubmed-5733469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57334692019-01-01 Stress leads to aberrant hippocampal involvement when processing schema-related information Vogel, Susanne Kluen, Lisa Marieke Fernández, Guillén Schwabe, Lars Learn Mem Research Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting schema activated by a specific cue. Participants’ memory for the presented material was tested 3–5 d after encoding. Overall, the processing of schema-related information activated the mPFC, the precuneus, and the angular gyrus. Stress resulted in aberrant hippocampal activity and connectivity while participants processed schema-related information. This aberrant engagement of the hippocampus was linked to altered subsequent memory. These findings suggest that stress may interfere with the efficient use of prior knowledge during encoding and may have important practical implications, in particular for educational settings. Cold Spring Harbor Laboratory Press 2018-01 /pmc/articles/PMC5733469/ /pubmed/29246978 http://dx.doi.org/10.1101/lm.046003.117 Text en © 2018 Vogel et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Vogel, Susanne Kluen, Lisa Marieke Fernández, Guillén Schwabe, Lars Stress leads to aberrant hippocampal involvement when processing schema-related information |
title | Stress leads to aberrant hippocampal involvement when processing schema-related information |
title_full | Stress leads to aberrant hippocampal involvement when processing schema-related information |
title_fullStr | Stress leads to aberrant hippocampal involvement when processing schema-related information |
title_full_unstemmed | Stress leads to aberrant hippocampal involvement when processing schema-related information |
title_short | Stress leads to aberrant hippocampal involvement when processing schema-related information |
title_sort | stress leads to aberrant hippocampal involvement when processing schema-related information |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733469/ https://www.ncbi.nlm.nih.gov/pubmed/29246978 http://dx.doi.org/10.1101/lm.046003.117 |
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