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Stress leads to aberrant hippocampal involvement when processing schema-related information

Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus,...

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Detalles Bibliográficos
Autores principales: Vogel, Susanne, Kluen, Lisa Marieke, Fernández, Guillén, Schwabe, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733469/
https://www.ncbi.nlm.nih.gov/pubmed/29246978
http://dx.doi.org/10.1101/lm.046003.117
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author Vogel, Susanne
Kluen, Lisa Marieke
Fernández, Guillén
Schwabe, Lars
author_facet Vogel, Susanne
Kluen, Lisa Marieke
Fernández, Guillén
Schwabe, Lars
author_sort Vogel, Susanne
collection PubMed
description Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting schema activated by a specific cue. Participants’ memory for the presented material was tested 3–5 d after encoding. Overall, the processing of schema-related information activated the mPFC, the precuneus, and the angular gyrus. Stress resulted in aberrant hippocampal activity and connectivity while participants processed schema-related information. This aberrant engagement of the hippocampus was linked to altered subsequent memory. These findings suggest that stress may interfere with the efficient use of prior knowledge during encoding and may have important practical implications, in particular for educational settings.
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spelling pubmed-57334692019-01-01 Stress leads to aberrant hippocampal involvement when processing schema-related information Vogel, Susanne Kluen, Lisa Marieke Fernández, Guillén Schwabe, Lars Learn Mem Research Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding schema-unrelated information but not for schema-related information. A recent study indicated that stress mediators may affect schema-related memory, but the underlying neural mechanisms are currently unknown. Here, we thus tested the impact of acute stress on neural processing of schema-related information. We exposed healthy participants to a stress or control manipulation before they processed, in the MRI scanner, words related or unrelated to a preexisting schema activated by a specific cue. Participants’ memory for the presented material was tested 3–5 d after encoding. Overall, the processing of schema-related information activated the mPFC, the precuneus, and the angular gyrus. Stress resulted in aberrant hippocampal activity and connectivity while participants processed schema-related information. This aberrant engagement of the hippocampus was linked to altered subsequent memory. These findings suggest that stress may interfere with the efficient use of prior knowledge during encoding and may have important practical implications, in particular for educational settings. Cold Spring Harbor Laboratory Press 2018-01 /pmc/articles/PMC5733469/ /pubmed/29246978 http://dx.doi.org/10.1101/lm.046003.117 Text en © 2018 Vogel et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Vogel, Susanne
Kluen, Lisa Marieke
Fernández, Guillén
Schwabe, Lars
Stress leads to aberrant hippocampal involvement when processing schema-related information
title Stress leads to aberrant hippocampal involvement when processing schema-related information
title_full Stress leads to aberrant hippocampal involvement when processing schema-related information
title_fullStr Stress leads to aberrant hippocampal involvement when processing schema-related information
title_full_unstemmed Stress leads to aberrant hippocampal involvement when processing schema-related information
title_short Stress leads to aberrant hippocampal involvement when processing schema-related information
title_sort stress leads to aberrant hippocampal involvement when processing schema-related information
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733469/
https://www.ncbi.nlm.nih.gov/pubmed/29246978
http://dx.doi.org/10.1101/lm.046003.117
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