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Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

There is limited knowledge about the metabolic reprogramming induced by cancer therapies and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K–AKT–mTOR signaling markedly decreased glycolysis and restrained tumor growth, these signaling and metabolic restr...

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Detalles Bibliográficos
Autores principales:	Lue, Hui-wen, Podolak, Jennifer, Kolahi, Kevin, Cheng, Larry, Rao, Soumya, Garg, Devin, Xue, Chang-Hui, Rantala, Juha K., Tyner, Jeffrey W., Thornburg, Kent L., Martinez-Acevedo, Ann, Liu, Jen-Jane, Amling, Christopher L., Truillet, Charles, Louie, Sharon M., Anderson, Kimberly E., Evans, Michael J., O'Donnell, Valerie B., Nomura, Daniel K., Drake, Justin M., Ritz, Anna, Thomas, George V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733498/ https://www.ncbi.nlm.nih.gov/pubmed/29138276 http://dx.doi.org/10.1101/gad.305292.117

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